{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:40:25Z","timestamp":1780566025495,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Fetal aberrant right subclavian artery (ARSA) is a relatively common sonographic finding. Several studies have reported a significant association between ARSA and Down syndrome, as well as 22q11.2 microdeletion. The objective of this study was to assess the risk of abnormal chromosomal microarray analysis (CMA) findings in a large cohort of pregnancies with fetal ARSA as an isolated, as well as a non\u2010isolated, sonographic anomaly. A secondary objective was to review the literature, examining the frequency of chromosomal microarray aberrations in fetuses with isolated ARSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from all pregnancies referred for invasive testing and CMA due to sonographic diagnosis of fetal ARSA, between 2013 and 2017, were obtained retrospectively from the computerized database of the Israeli Ministry of Health. The rate of clinically significant CMA findings in these fetuses was compared to that in a local control population of 2752 low\u2010risk pregnancies with normal ultrasound and serum screening results. In addition, a literature search was conducted in PubMed, from inception to February 2018, of original studies in the English language describing the frequency and nature of microscopic and submicroscopic aberrations in fetuses with isolated ARSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 246 pregnancies with isolated ARSA that underwent CMA analysis, a clinically significant finding was detected in one (0.4%) pregnancy (trisomy 21). This rate did not differ significantly from that in the control population (<jats:italic>P<\/jats:italic> = 0.1574). Of 22 fetuses with non\u2010isolated ARSA, one  (4.5%) additional case of trisomy 21 was noted. The frequency of trisomy 21 in this cohort also did not differ from that in the control population (relative risk, 5.5 (95% CI, 0.8\u201337.6)). The literature search yielded 13 additional relevant papers, encompassing 333 cases of isolated ARSA. Of 579 cases overall (including those of the present study), 13 (2.2%) cases of trisomy 21 were detected, with no cases of 22q11.2 microdeletion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While an association may exist between non\u2010isolated ARSA and Down syndrome, isolated ARSA might better serve as a soft marker for Down syndrome, rather than a routine indication for invasive prenatal testing. Copyright \u00a9 2018 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20208","type":"journal-article","created":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T05:14:26Z","timestamp":1545714866000},"page":"810-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Microarray analysis has no additional value in fetal aberrant right subclavian artery: description of 268 pregnancies and systematic literature review"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-2130","authenticated-orcid":false,"given":"L.","family":"Sagi\u2010Dain","sequence":"first","affiliation":[{"name":"Genetics Institute Carmel Medical Center, affiliated to the Ruth and Bruce Rappaport Faculty of Medicine, Technion \u2010 Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Singer","sequence":"additional","affiliation":[{"name":"Community Genetics, Public Health Services Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Josefsberg","sequence":"additional","affiliation":[{"name":"Genetics Institute Kaplan Medical Center  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Peleg","sequence":"additional","affiliation":[{"name":"Genetics Institute Carmel Medical Center, affiliated to the Ruth and Bruce Rappaport Faculty of Medicine, Technion \u2010 Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lev","sequence":"additional","affiliation":[{"name":"The Rina Mor Institute of Medical Genetics Wolfson Medical Center  Holon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Nasser","family":"Samra","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ziv Medical Center  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bar\u2010Shira","sequence":"additional","affiliation":[{"name":"The Genetic Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zeligson","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute Shaare Zedek Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Maya","sequence":"additional","affiliation":[{"name":"Recanati Genetics Institute Beilinson Hospital, Rabin Medical Center  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ben\u2010Shachar","sequence":"additional","affiliation":[{"name":"The Genetic Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00795645"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4042"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.080"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3942"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01286-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5230"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7683"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12364"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14774"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12575"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4209"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001405"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15935"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5092"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182217a3a"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0550-x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5226"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2678"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1907-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245935"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354650"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13336"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443524"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40556-016-0104-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.05075"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.05028"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.16046"}],"container-title":["Ultrasound in Obstetrics &amp; 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