{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:03:07Z","timestamp":1788080587592,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Fetal endoscopic tracheal occlusion (FETO) is associated with increased perinatal survival and reduced need for extracorporeal membrane oxygenation (ECMO) in fetuses with severe congenital diaphragmatic hernia (CDH). This study evaluates the impact of FETO on the resolution of pulmonary hypertension (PH) in fetuses with isolated CDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed retrospectively the medical records of all fetuses evaluated for CDH between January 2004 and July 2017 at a single institution. Fetuses with additional major structural or chromosomal abnormalities were excluded. CDH cases were classified retrospectively into mild, moderate and severe groups based on prenatal magnetic resonance imaging indices (observed\u2010to\u2010expected total fetal lung volume and percentage of intrathoracic liver herniation). Presence of PH was determined based on postnatal echocardiograms. Logistic regression analyses were performed to evaluate the relationship between FETO and resolution of PH by 1\u2009year of age while controlling for side of the CDH, use of ECMO, gestational age at diagnosis, gestational age at delivery, fetal gender, sildenafil use at discharge and CDH severity. Resolution of PH by 1\u2009year of age was compared between a cohort of fetuses with severe CDH that underwent FETO and a cohort that did not have the procedure (non\u2010FETO). A subanalysis was performed restricting the analysis to isolated left CDH. Parametric and non\u2010parametric tests were used for comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 257 CDH cases evaluated, 72% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009184) had no major structural or chromosomal anomalies of which 58% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009107) met the study inclusion criteria. The FETO cohort consisted of 19 CDH cases and the non\u2010FETO cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200988) consisted of 31 (35%) mild, 32 (36%) moderate and 25 (28%) severe CDH cases. All infants with severe CDH, regardless of whether they underwent FETO, had evidence of neonatal PH. FETO (OR, 3.57; 95%\u2009CI, 1.05\u201312.10;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.041) and ECMO (OR, 5.01; 95%\u2009CI, 2.10\u201311.96;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independent predictors of resolution of PH by 1\u2009year of age. A higher proportion of infants with severe CDH that underwent FETO had resolution of PH by 1\u2009year after birth compared with infants with severe CDH in the non\u2010FETO cohort (69% (11\/16)\n                      <jats:italic>vs<\/jats:italic>\n                      28% (7\/25);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017). Similar results were observed when the analysis was restricted to cases with left\u2010sided CDH (PH resolution in 69% (11\/16)\n                      <jats:italic>vs<\/jats:italic>\n                      28% (5\/18);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In infants with severe CDH, FETO and ECMO are independently associated with increased resolution of PH by 1\u2009year of age. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.20216","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T09:54:08Z","timestamp":1547459648000},"page":"752-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Fetal endoscopic tracheal occlusion reduces pulmonary hypertension in severe congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"54","author":[{"given":"C. C.","family":"Style","sequence":"first","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"The Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. O.","family":"Olutoye","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"The Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Belfort","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"Department of Obstetrics &amp; Gynecology, Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Ayres","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"Department of Pediatrics, Cardiology Section Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"The Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. E.","family":"Lau","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"The Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Shamshirsaz","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"Department of Obstetrics &amp; Gynecology, Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"The Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. A.","family":"Olutoye","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"Department of Anesthesiology Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"Department of Pediatrics, Newborn Section Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanz Cortes","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"Department of Obstetrics &amp; Gynecology, Division of Maternal\u2010Fetal Medicine Baylor College of Medicine &amp; Texas Children's Hospital  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Keswani","sequence":"additional","affiliation":[{"name":"Texas Children's Fetal Center, Baylor College of Medicine  Houston TX USA"},{"name":"The Michael E. 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