{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:38Z","timestamp":1786978598247,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","award":["(Charity No. 1037116)"],"award-info":[{"award-number":["(Charity No. 1037116)"]}],"id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2019,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To evaluate the performance of ultrasonographic estimated fetal weight (EFW) at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation in the prediction of delivery of a small\u2010for\u2010gestational\u2010age (SGA) neonate and assess the additive value of, first, maternal risk factors and, second, fetal growth velocity between 20 and 36\u2009weeks' gestation in improving such prediction.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective study of 44\u2009043 singleton pregnancies undergoing routine ultrasound examination at 19\u2009+\u20090 to 23\u2009+\u20096 and at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation. Multivariable logistic regression analysis was used to determine whether addition of maternal risk factors and growth velocity, the latter defined as the difference in EFW\n Z<\/jats:italic>\n \u2010score or fetal abdominal circumference (AC)\n Z<\/jats:italic>\n \u2010score between the third\u2010 and second\u2010trimester scans divided by the time interval between the scans, improved the performance of EFW\n Z<\/jats:italic>\n \u2010score at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks in the prediction of delivery of a SGA neonate with birth weight <\u200910\n th<\/jats:sup>\n and <\u20093\n rd<\/jats:sup>\n percentiles within 2\u2009weeks and at any stage after assessment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Screening by EFW\n Z<\/jats:italic>\n \u2010score at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation predicted 63.4% (95% CI, 62.0\u201364.7%) of neonates with birth weight <\u200910\n th<\/jats:sup>\n percentile and 74.2% (95% CI, 72.2\u201376.1%) of neonates with birth weight <\u20093\n rd<\/jats:sup>\n percentile born at any stage after assessment, at a screen\u2010positive rate of 10%. The respective values for SGA neonates born within 2\u2009weeks after assessment were 76.8% (95% CI, 74.4\u201379.0%) and 81.3% (95% CI, 78.2\u201384.0%). For a desired 90% detection rate of SGA neonate delivered at any stage after assessment, the necessary screen\u2010positive rate would be 33.7% for SGA\u2009<\u200910\n th<\/jats:sup>\n percentile and 24.4% for SGA\u2009<\u20093\n rd<\/jats:sup>\n percentile. Multivariable logistic regression analysis demonstrated that, in the prediction of a SGA neonate with birth weight <\u200910\n th<\/jats:sup>\n and <\u20093\n rd<\/jats:sup>\n percentiles, there was a significant contribution from EFW\n Z<\/jats:italic>\n \u2010score at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation, maternal risk factors and AC growth velocity, but not EFW growth velocity. However, the area under the receiver\u2013operating characteristics curve for prediction of delivery of a SGA neonate by screening with maternal risk factors and EFW\n Z<\/jats:italic>\n \u2010score was not improved by addition of AC growth velocity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Screening for SGA neonates by EFW at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation and use of the 10\n th<\/jats:sup>\n percentile as the cut\u2010off predicts 63% of affected neonates. Prediction of 90% of SGA neonates necessitates classification of about 35% of the population as being screen positive. The predictive performance of EFW is not improved by addition of estimated growth velocity between the second and third trimesters of pregnancy. Copyright \u00a9 2019 ISUOG. Published by John Wiley & Sons Ltd.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.20243","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T03:41:56Z","timestamp":1550547716000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Prediction of small\u2010for\u2010gestational\u2010age neonates at 35\u201337\u2009weeks' gestation: contribution of maternal factors and growth velocity between 20 and 36\u2009weeks"],"prefix":"10.1002","volume":"53","author":[{"given":"A.","family":"Ciobanu","sequence":"first","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Formuso","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-5442","authenticated-orcid":false,"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Medway Maritime Hospital Gillingham UK"},{"name":"Institute of Medical Sciences Canterbury Christ Church University Chatham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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