{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:12:52Z","timestamp":1747455172306,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"regional authority of Northern Norway","award":["Project no. 12050"],"award-info":[{"award-number":["Project no. 12050"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the effect of hypoxemia on fetal heart rate (FHR) variability, using an instrumented pregnant sheep model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, 19 pregnant sheep were instrumented under general anesthesia, at a mean gestational age of 127\u2009days. After a 5\u2010day recovery period, hypoxemia was induced by attaching the mother to a rebreathing circuit. Hypoxemia was sustained for 120\u2009min, following which it was reversed until maternal and fetal partial pressure of oxygen (pO<jats:sub>2<\/jats:sub>) returned to baseline. FHR recordings at baseline, after 30 and 120\u2009min of hypoxemia and at recovery were analyzed to calculate short\u2010term variation (STV) in 16\u2009epochs of 3.75\u2009s, every minute. Phase\u2010rectified signal averaging (window length (L)\u2009=\u200910, time (T)\u2009=\u20092 and scale (S)\u2009=\u20092) was used to calculate FHR acceleration (AC) and deceleration (DC) capacities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, mean\u2009\u00b1\u2009SD fetal pO<jats:sub>2<\/jats:sub> was 2.90\u2009\u00b1\u20090.38\u2009kPa. Acute hypoxemia was associated with a significant reduction in mean pO<jats:sub>2<\/jats:sub> at 30 (1.62\u2009\u00b1\u20090.37\u2009kPa) and 120 (1.51\u2009\u00b1\u20090.16\u2009kPa) min. Mean\u2009\u00b1\u2009SD fetal pO<jats:sub>2<\/jats:sub> at recovery was 2.86\u2009\u00b1\u20090.32\u2009kPa. At baseline, median STV, AC and DC were 1.307 (interquartile range (IQR), 0.515\u20132.508) ms, 1.295 (IQR, 0.990\u20132.685) beats per minute (bpm) and 1.197 (IQR, 0.850\u20131.836) bpm, respectively. At 30\u2009min of hypoxemia, the values were 1.323 (IQR, 0.753\u20132.744) ms, 1.696 (IQR, 1.310\u20133.013) bpm and 1.584 (IQR, 1.217\u20134.132) bpm, respectively. At 120\u2009min of hypoxemia, they were 1.760 (IQR, 0.928\u20134.656) ms, 3.098 (IQR, 1.530\u20135.163) bpm and 3.054 (IQR, 1.508\u20134.522) bpm, respectively. At recovery, they changed to 0.962 (IQR, 0.703\u20131.154) ms, 1.228 (IQR, 1.071\u20132.234) bpm and 1.086 (IQR, 0.873\u20131.568) bpm, respectively. Hypoxemia for 30 and 120\u2009min was associated with a significant increase in DC compared to baseline (<jats:italic>P<\/jats:italic>\u2009=\u20090.014 and 0.017, respectively). The changes in STV and AC were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute hypoxemia is associated with a significant increase in the DC of FHR in a fetal sheep model. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20259","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T02:38:16Z","timestamp":1552531096000},"page":"786-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fetal heart rate variability with hypoxemia in an instrumented sheep model"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2393-7501","authenticated-orcid":false,"given":"A.","family":"Bhide","sequence":"first","affiliation":[{"name":"Women's Health and Perinatology Research Group, Department of Clinical Medicine UiT \u2010 Arctic University of Troms\u00f8  Troms\u00f8 Norway"},{"name":"Fetal Medicine Unit St George's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention &amp; 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