{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:53:35Z","timestamp":1778637215879,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical and ultrasound characteristics of serous cystadenofibromas in the adnexa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of patients identified in the International Ovarian Tumor Analysis (IOTA) database, who had a histological diagnosis of serous cystadenofibroma and had undergone preoperative ultrasound examination by an experienced ultrasound examiner, between 1999 and 2012. In the IOTA database, which contains data collected prospectively, the tumors were described using the terms and definitions of the IOTA group. In addition, three authors reviewed, first independently and then together, ultrasound images of serous cystadenofibromas and described them using pattern recognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 233 women with a histological diagnosis of serous cystadenofibroma. In the IOTA database, most cystadenofibromas (67.4%; 157\/233) were described as containing solid components but 19.3% (45\/233) were described as multilocular cysts and 13.3% (31\/233) as unilocular cysts. Papillary projections were described in 52.4% (122\/233) of the cystadenofibromas. In 79.5% (97\/122) of the cysts with papillary projections, color Doppler signals were absent in the papillary projections. Most cystadenofibromas (83.7%; 195\/233) manifested no or minimal color Doppler signals. On retrospective analysis of 201 ultrasound images of serous cystadenofibromas, using pattern recognition, 10 major types of ultrasound appearance were identified. The most common pattern was a unilocular solid cyst with one or more papillary projections, but no other solid components (25.9%; 52\/201). The second most common pattern was a multilocular solid mass with small solid component(s), but no papillary projections (19.4%; 39\/201). The third and fourth most common patterns were multi\u2010 or bilocular cyst (16.9%; 34\/201) and unilocular cyst (11.9%; 24\/201). Using pattern recognition, shadowing was identified in 39.8% (80\/201) of the tumors, and microcystic appearance of the papillary projections was observed in 34 (38.6%) of the 88 tumors containing papillary projections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ultrasound features of serous cystadenofibromas vary. The most common pattern is a unilocular solid cyst with one or more papillary projections but no other solid components, with absent color Doppler signals. Most serous cystadenofibromas were poorly vascularized on color Doppler examination and many manifested acoustic shadowing. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20277","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T06:11:51Z","timestamp":1554185511000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Imaging in gynecological disease (16): clinical and ultrasound characteristics of serous cystadenofibromas in adnexa"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-7468","authenticated-orcid":false,"given":"B. A.","family":"Virgilio","sequence":"first","affiliation":[{"name":"Istituto di Ginecologia ed Ostetricia Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Department of Obstetrics and Gynecology Policlinico Hospital  Abano Terme, Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-0909","authenticated-orcid":false,"given":"I.","family":"De Blasis","sequence":"additional","affiliation":[{"name":"Istituto di Ginecologia ed Ostetricia Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-8135","authenticated-orcid":false,"given":"P.","family":"Sladkevicius","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-7245","authenticated-orcid":false,"given":"F.","family":"Moro","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Zannoni","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze della Salute della Donna e del Bambino, Unit\u00e0 di Ginecopatologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Arciuolo","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze della Salute della Donna e del Bambino, Unit\u00e0 di Ginecopatologia Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mascilini","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ciccarone","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospitals Katholieke Universiteit Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kaijser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospitals Katholieke Universiteit Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fruscio","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynecology, Department of Medicine and Surgery San Gerardo Hospital, University of Milan\u2010Bicocca  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Van Holsbeke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Franchi","sequence":"additional","affiliation":[{"name":"Preventive Gynecology Unit, Division of Gynecology, European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-7785","authenticated-orcid":false,"given":"E.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Obstetrics and Gynecology S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. P. G.","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Clinical Sciences Institute  L. Sacco, Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-7155","authenticated-orcid":false,"given":"S.","family":"Guerriero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Cagliari, Policlinico Universitario Duilio Casula  Monserrato, Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Czekierdowski","sequence":"additional","affiliation":[{"name":"First Department of Gynecological Oncology and Gynecology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Scambia","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Testa","sequence":"additional","affiliation":[{"name":"Istituto di Ginecologia ed Ostetricia Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Valentin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Institution of Clinical Sciences Malm\u00f6 Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-58564-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/978-1-4419-0489-8","volume-title":"Blaustein's pathology of the female genital tract","author":"Kurman RJ","year":"2011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00415-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.10.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197412)34:6<1971::AID-CNCR2820340616>3.0.CO;2-N"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-181"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)90253-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0785-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.5.1821259"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.7632"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0113"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7636"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.333"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00287.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14050338.x"},{"key":"e_1_2_7_17_1","first-page":"17","volume-title":"WHO Classification of Tumours of Female Reproductive Organs","author":"Longacre TA","year":"2014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.8.915"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22241"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6607"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22266"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2707"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9030"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12294"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18951"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20283"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.20277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:48:44Z","timestamp":1694015324000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.20277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/uog.20277"],"URL":"https:\/\/doi.org\/10.1002\/uog.20277","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2018-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}