{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:32:57Z","timestamp":1791401577350,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the perinatal outcome of singleton pregnancies complicated by placental chorioangioma diagnosed on prenatal ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE, CINAHL and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> databases were searched for studies reporting the outcome of pregnancies complicated by placental chorioangioma. Inclusion criteria were singleton pregnancy diagnosed with placental chorioangioma on prenatal ultrasound, with no other associated structural anomaly. The primary outcome was perinatal mortality. Secondary outcomes included associated non\u2010structural anomalies detected on prenatal ultrasound (including fetal hydrops, anemia, polyhydramnios, signs of hyperdynamic circulation and small\u2010for\u2010gestational\u2010age (SGA) fetus), SGA at birth, composite neonatal morbidity and preterm birth. Outcome was assessed separately in pregnancies undergoing and those not undergoing fetal therapy. Subanalyses were performed according to the presence of hydrops and the size of the tumor in all pregnancies diagnosed with chorioangioma. Random\u2010effects meta\u2010analyses of proportions were used to analyze the \ndata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight studies (161 pregnancies) were included. In pregnancies complicated by chorioangioma that did not undergo intervention, intrauterine death occurred in 8.2% (95%\u2009CI, 3.8\u201315.0%), while neonatal death and perinatal death occurred in 3.8% (95%\u2009CI, 1.0\u20138.1%) and 11.1% (95%\u2009CI, 5.0\u201319.4%), respectively. SGA at birth was present in 24.0% (95%\u2009CI, 13.5\u201336.5%) of cases, while preterm birth &lt;\u200937\u2009weeks complicated 34.1% (95%\u2009CI, 21.1\u201348.3%) of pregnancies. Composite neonatal morbidity occurred in 12.0% (95%\u2009CI, 4.5\u201322.3%) of cases. On ultrasound, signs of fetal hyperdynamic circulation were present in 21.0% (95%\u2009CI, 9.6\u201335.3%) of cases, while peak systolic velocity in the fetal middle cerebral artery was increased in 20.6% (95%\u2009CI, 10.9\u201332.3%). Subanalysis according to the size of chorioangioma, including both pregnancies that did and those that did not undergo intervention, showed a progressive increase in the occurrence of most of the outcomes explored with increasing size of the tumor. Furthermore, the prevalence of adverse perinatal outcome was high in pregnancies complicated by chorioangioma presenting with fetal hydrops. There was no randomized controlled trial comparing intervention <jats:italic>vs<\/jats:italic> expectant management in pregnancies complicated by chorioangioma with signs of fetal compromise (hydrops or hyperdynamic circulation). Overall, perinatal mortality occurred in 31.2% (95%\u2009CI, 18.1\u201346.1%) of fetuses undergoing <jats:italic>in\u2010utero<\/jats:italic> therapy, and 57.3% (95%\u2009CI, 39.2\u201374.4%) had resolution of hydrops or hyperdynamic circulation after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Placental chorioangioma is associated with adverse perinatal outcome. The size of the mass and presence of fetal hydrops are likely to be the main determinants of perinatal outcome in affected pregnancies. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20304","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:21:35Z","timestamp":1556670095000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"55","author":[{"given":"D.","family":"Buca","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Iacovella","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Goethe University  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust, University of London  London UK"},{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-4353","authenticated-orcid":false,"given":"G.","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine, Ospedale Cristo Re University of Rome Tor Vergata  Rome Italy"},{"name":"Department of Obstetrics and Gynecology I.M. 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