{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:29:54Z","timestamp":1762867794470,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the effectiveness of single and repeat sonographic cervical\u2010length (CL) measurement in predicting preterm delivery in symptomatic women with a twin pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of women with a twin gestation who presented with painful and regular uterine contractions at 24\u2009+\u20090 to 33\u2009+\u20096\u2009weeks' gestation at the perinatal unit of the University Hospital of T\u00fcbingen, T\u00fcbingen, Germany between 2012 and 2018. CL was measured on transvaginal ultrasound at the time of admission and a few days later after cessation of contractions. Treatment included administration of tocolytics (usually oral nifedipine), for no more than 48\u2009h, and administration of steroids if CL was \u2264\u200925\u2009mm. Patients were clustered into five groups according to the CL measurement obtained at first assessment: &lt;\u200910.0\u2009mm; between 10.0 and 14.9\u2009mm; between 15.0 and 19.9\u2009mm; between 20.0 and 24.9\u2009mm; and \u2265\u200925.0\u2009mm. For each group, we calculated the test performance of CL measurement for prediction of preterm delivery within the subsequent 7\u2009days and before 34\u2009weeks' gestation. Regression analysis was used to evaluate the test performance of the second CL measurement for predicting preterm delivery within 7\u2009days after the second assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population consisted of 257 twin pregnancies, of which 80.2% were dichorionic diamniotic. Median maternal and gestational ages at the time of admission were 32.0\u2009years and 29.9\u2009weeks' gestation, respectively. Preterm birth within 7\u2009days of admission occurred in 23 (8.9%) pregnancies, and 82 (31.9%) patients delivered prior to 34\u2009weeks' gestation. Median CL for the entire study population was 17.0\u2009mm. Delivery within 7\u2009days after the first assessment occurred in 29.0%, 10.6%, 4.2%, 6.3% and 0% of women with CL &lt;\u200910.0\u2009mm, 10.0\u201314.9\u2009mm, 15.0\u201319.9\u2009mm, 20.0\u201324.9\u2009mm and \u2265\u200925.0\u2009mm, respectively. There was a weak, but significant, association between the CL measurement at the time of admission and the time interval between admission and delivery (interval\u2009=\u200927.9\u2009+\u20090.58\u2009\u00d7\u2009CL; <jats:italic>P<\/jats:italic>\u2009=\u20090.003, <jats:italic>r<\/jats:italic>\u2009=\u20090.184).<\/jats:p><jats:p>CL was measured again after a median time interval of 3 (interquartile range (IQR), 2\u20135) days in 248 cases. Median second CL measurement was 17.0 (IQR, 11.5\u201322.0) mm. Delivery occurred within the subsequent 7\u2009days after the second measurement in 25\/248 (10.1%) cases. Binary regression analysis indicated that the first (odds ratio (OR), 0.895; <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and second (OR, 0.908; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) CL measurements, but not the difference between the two measurements (OR, 0.961; <jats:italic>P<\/jats:italic>\u2009=\u20090.361), were associated significantly with delivery within 7\u2009days after the second measurement. Receiver\u2010operating\u2010characteristics (ROC)\u2010curve analysis for the prediction of delivery within 7\u2009days after the second assessment did not show a significant difference between the predictive performance of the first (area under ROC curve (AUC), 0.676 (95%\u2009CI, 0.559\u20130.793)) and the second (AUC, 0.661 (95%\u2009CI, 0.531\u20130.790)) measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sonographic measurement of CL can be helpful in predicting preterm delivery within 7\u2009days of presentation in symptomatic women with a twin gestation; however, the test performance is relatively \nweak. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20306","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T09:30:03Z","timestamp":1557307803000},"page":"496-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Single and repeat cervical\u2010length measurement in twin gestation with threatened preterm labor"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3052-5786","authenticated-orcid":false,"given":"N.","family":"Prodan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sonek","sequence":"additional","affiliation":[{"name":"Fetal Medicine Foundation USA, Dayton, OH, USA"},{"name":"Division of Maternal Fetal Medicine Wright State University  Dayton OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Abele","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hoopmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-5143","authenticated-orcid":false,"given":"K. O.","family":"Kagan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13430"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17388"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15173"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7457"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.02.064"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14665"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/125897"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14742"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-104282"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.10.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.951"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.07.047"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.06.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.05.018"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.499484"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.926883"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20447-5"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.20306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.20306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:41:24Z","timestamp":1694032884000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.20306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/uog.20306"],"URL":"https:\/\/doi.org\/10.1002\/uog.20306","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"type":"print","value":"0960-7692"},{"type":"electronic","value":"1469-0705"}],"subject":[],"published":{"date-parts":[[2020,3,31]]},"assertion":[{"value":"2019-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}