{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:14:25Z","timestamp":1763810065011,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T00:00:00Z","timestamp":1585440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Selective fetal growth restriction (sFGR) occurs in monochorionic twin pregnancies when unequal placental sharing leads to restriction in the growth of just one twin. Management options include laser separation of the fetal circulations, selective reduction or expectant management, but what constitutes the best treatment is not yet known. New trials in this area are urgently needed but, in this rare and complex group, maximizing the relevance and utility of clinical research design and outputs is paramount. A core outcome set ensures standardized outcome collection and reporting in future research. The objective of this study was to develop a core outcome set for studies evaluating treatments for sFGR in monochorionic twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international steering group of clinicians, researchers and patients with experience of sFGR was established to oversee the process of development of a core outcome set for studies investigating the management of sFGR. Outcomes reported in the literature were identified through a systematic review and informed the design of a three\u2010round Delphi survey. Clinicians, researchers, and patients and family representatives participated in the survey. Outcomes were scored on a Likert scale from 1 (limited importance for making a decision) to 9 (critical for making a decision). Consensus was defined <jats:italic>a\u2009priori<\/jats:italic> as a Likert score of \u2265\u20098 in the third round of the Delphi survey. Participants were then invited to take part in an international meeting of stakeholders in which the modified nominal group technique was used to consider the consensus outcomes and agree on a final core outcome \nset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six outcomes were identified from 39 studies in the systematic review. One hundred and three participants from 23 countries completed the first round of the Delphi survey, of whom 88 completed all three rounds. Twenty\u2010nine outcomes met the <jats:italic>a\u2009priori<\/jats:italic> criteria for consensus and, along with six additional outcomes, were prioritized in a consensus development meeting, using the modified nominal group technique. Twenty\u2010five stakeholders participated in this meeting, including researchers (<jats:italic>n<\/jats:italic>\u2009=\u20093), fetal medicine specialists (<jats:italic>n<\/jats:italic>\u2009=\u20093), obstetricians (<jats:italic>n<\/jats:italic>\u2009=\u20092), neonatologists (<jats:italic>n<\/jats:italic>\u2009=\u20093), midwives (<jats:italic>n<\/jats:italic>\u2009=\u20094), parents and family members (<jats:italic>n<\/jats:italic>\u2009=\u20096), patient group representatives (<jats:italic>n<\/jats:italic>\u2009=\u20093), and a sonographer. Eleven core outcomes were agreed upon. These were live birth, gestational age at birth, birth weight, intertwin birth\u2010weight discordance, death of surviving twin after death of cotwin, loss during pregnancy or before final hospital discharge, parental stress, procedure\u2010related adverse maternal outcome, length of neonatal stay in hospital, neurological abnormality on postnatal imaging and childhood disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This core outcome set for studies investigating the management of sFGR represents the consensus of a large and diverse group of international collaborators. Use of these outcomes in future trials should help to increase the clinical relevance of research on this condition. Consensus agreement on core outcome definitions and measures is now required. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20388","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T05:22:53Z","timestamp":1562304173000},"page":"652-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Core outcome set for studies investigating management of selective fetal growth restriction in twins"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-7069","authenticated-orcid":false,"given":"R.","family":"Townsend","sequence":"first","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London  London UK"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. N.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Balliol College University of Oxford  Oxford UK"},{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-0576","authenticated-orcid":false,"given":"F.","family":"Sileo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-045X","authenticated-orcid":false,"given":"H.","family":"Perry","sequence":"additional","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London  London UK"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2115","authenticated-orcid":false,"given":"W.","family":"Ganzevoort","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Reed","sequence":"additional","affiliation":[{"name":"Twin and Multiple Births Association (TAMBA)  Aldershot UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-2084","authenticated-orcid":false,"given":"A. A.","family":"Baschat","sequence":"additional","affiliation":[{"name":"The Johns Hopkins Center for Fetal Therapy  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"J.","family":"Deprest","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospitals of KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine, Hospital Cl\u00ednic and Hospital Sant Joan de Deu Universitat de Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hecher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lewi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospitals of KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-2232","authenticated-orcid":false,"given":"A.","family":"Papageorghiou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Gordijn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute St George's University of London  London UK"},{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology St George's University Hospitals NHS Foundation Trust, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the International Collaboration to Harmonise Outcomes for Selective Fetal Growth Restriction (CHOOSE\u2010FGR)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,29]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1002\/uog.17362"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1002\/uog.19013"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1002\/uog.20114"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1002\/uog.19192"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1016\/j.ajog.2018.09.023"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1111\/1471-0528.14694"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1111\/1471-0528.14438"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1186\/s13063-017-1978-4"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1111\/1471-0528.15616"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1186\/s12913-018-3732-3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1002\/uog.20183"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1097\/AOG.0000000000001195"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1002\/uog.20189"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1136\/bmjpo-2017-000048"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1186\/s13063-018-3153-y"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1001\/jama.2015.3656"},{"key":"e_1_2_6_18_1","first-page":"10","article-title":"The Delphi technique: making sense of consensus","volume":"12","author":"Hsu C\u2010C","year":"2007","journal-title":"Pract Assess Res Eval"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1371\/journal.pmed.1000393"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1186\/s12874-016-0210-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1046\/j.1365-2648.1996.09623.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.1302\/0301-620X.96B8.33766"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.1007\/s10742-014-0121-1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.1002\/uog.20294"},{"unstructured":"EastwoodMP.Perinatal Solutions for Congenital Diaphragmatic Hernia. Thesis LIRIAS1658272 KU Leuven 2017.","key":"e_1_2_6_25_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.1016\/j.ajog.2018.01.013"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_1","DOI":"10.1016\/0272-7358(88)90050-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_28_1","DOI":"10.1186\/s13063-016-1555-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_29_1","DOI":"10.1111\/1471-0528.15409"},{"doi-asserted-by":"publisher","key":"e_1_2_6_30_1","DOI":"10.1111\/jog.13034"},{"volume-title":"Towards a Common Language for Functioning, Disability and Health ICF","year":"2002","author":"World Health Organization (WHO)","key":"e_1_2_6_31_1"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.20388","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:56:58Z","timestamp":1693958218000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.20388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,29]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/uog.20388"],"URL":"https:\/\/doi.org\/10.1002\/uog.20388","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"type":"print","value":"0960-7692"},{"type":"electronic","value":"1469-0705"}],"subject":[],"published":{"date-parts":[[2020,3,29]]},"assertion":[{"value":"2019-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}