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The French REPERE study was conducted to estimate the association between antenatal detection of FGR and risk of stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>REPERE is a case\u2013control study performed in three French districts with a combined total of approximately 30\u2009000 births annually. Cases were singleton small\u2010for\u2010gestational\u2010age (SGA) stillbirths \u2265\u200924\u2009weeks' gestation and without severe congenital anomaly, between 2012 and 2014, identified using a population\u2010based stillbirth registry; controls were live births fulfilling the same inclusion criteria over a 9\u2010week period from 7 April to 8 June 2014. Data were extracted by trained investigators from medical records and ultrasound reports. SGA was defined as birth weight &lt;\u200910<jats:sup>th<\/jats:sup> percentile of French customized standards. FGR was defined by the presence of at least one of seven predefined parameters (suspected FGR mentioned in medical records or in ultrasound report, suspected faltering growth mentioned in an ultrasound report, documented abdominal circumference or estimated fetal weight &lt;\u200910<jats:sup>th<\/jats:sup> percentile, referral for additional ultrasound examination to monitor growth or abnormal umbilical artery Doppler). We used logistic regression to estimate crude and adjusted odds ratios (ORs) for the association between detection of FGR and risk of stillbirth. Included covariables were parity, maternal medical history, vascular complications during pregnancy and birth\u2010weight percentile, which are known to be associated with risk of detection of FGR and of stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, there were 92\u2009182 births \u2265\u200922\u2009weeks' gestation, including 669 stillbirths, of which 79 were singleton SGA stillbirths \u2265\u200924\u2009weeks and without severe congenital anomaly. Of these cases, 44.3% (35\/79) had FGR detected, compared with a detection rate of 36.2% in controls (154\/426). The crude OR expressing the association between detection of FGR and risk of stillbirth was 1.4 (95%\u2009CI, 0.9\u20132.3) and the OR adjusted for parity, presence of risk factors for FGR, presence of vascular disorder and birth\u2010weight percentile was 0.6 (95%\u2009CI, 0.3\u20131.0). Among deliveries \u2265\u200928\u2009weeks, detection rates were 38.3% <jats:italic>vs<\/jats:italic> 36.0% for cases and controls, with an adjusted OR of 0.5 (95%\u2009CI, 0.2\u20131.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antenatal detection of FGR was protective against stillbirth, but over 40% of stillbirths among SGA fetuses occurred despite detection of FGR, pointing to the need to improve management following detection. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20414","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T08:43:48Z","timestamp":1564562628000},"page":"613-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Antenatal detection of fetal growth restriction and risk of stillbirth: population\u2010based case\u2013control study"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-910X","authenticated-orcid":false,"given":"A.","family":"Ego","sequence":"first","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, CNRS, Public Health Department CHU Grenoble Alpes, Grenoble INP (Grenoble Institute of Engineering), TIMC\u2010IMAG  Grenoble France"},{"name":"INSERM CIC U1406  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-7322","authenticated-orcid":false,"given":"I.","family":"Monier","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153, Obstetric, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics, Paris\u2010Descartes University  Paris France"},{"name":"Antoine B\u00e9cl\u00e8re Maternity Unit, Department of Obstetrics and Gynaecology Universit\u00e9 Paris Sud  AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Skaare","sequence":"additional","affiliation":[{"name":"INSERM CIC U1406  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-2969","authenticated-orcid":false,"given":"J.","family":"Zeitlin","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153, Obstetric, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics, Paris\u2010Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01020-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14939"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14971"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00837-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62233-7"},{"key":"e_1_2_7_8_1","unstructured":"Royal College of Obstetricians and Gynaecologists. 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