{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:03:04Z","timestamp":1791925384630,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The Hypertension and Preeclampsia Intervention Trial At near Term\u2010I (HYPITAT\u2010I) randomized controlled trial showed that, in women with gestational hypertension or mild pre\u2010eclampsia at term, induction of labor, compared with expectant management, was associated with improved maternal outcome without compromising neonatal outcome. The aim of the current study was to evaluate the impact of these findings on obstetric management and maternal and perinatal outcomes in The Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved data for the period 2000\u20132014 from the Dutch National Perinatal Registry, including 143\u2009749 women with gestational hypertension or pre\u2010eclampsia and a singleton fetus in cephalic presentation, delivered between 36\u2009+\u20090 and 40\u2009+\u20096\u2009weeks of gestation (hypertensive disorder of pregnancy (HDP) group). Pregnant women without HDP were used as the reference group (<jats:italic>n<\/jats:italic>\u2009=\u20091\u2009649\u2009510). The HYPITAT\u2010I trial was conducted between 2005 and 2008. To study the impact of HYPITAT\u2010I, we compared rate of induction of labor, mode of delivery and maternal and perinatal outcomes in the periods before (2000\u20132005) and after (2008\u20132014) the trial. We also differentiated between hospitals that participated in HYPITAT\u2010I and those that did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the HDP group, the rate of induction of labor increased from 51.1% before the HYPITAT\u2010I trial to 64.2% after it (relative risk (RR), 1.26; 95%\u00a0CI, 1.24\u20131.27). Maternal mortality decreased from 0.022% before the trial to 0.004% after it (RR, 0.20; 95%\u00a0CI, 0.06\u20130.70) and perinatal death decreased from 0.49% to 0.27% (RR, 0.54; 95%\u00a0CI, 0.45\u20130.65), which was attributable mostly to a decrease in fetal death. Both the increase in induction rate and the reduction in hypertensive complications were more pronounced in hospitals that participated in the HYPITAT\u2010I trial than in those that did not. Following HYPITAT\u2010I, the rate of induction of labor also increased (by 4.6 percentage points) in the reference group; however, the relative increase in the HDP group (13.1 percentage points) was significantly greater (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for the interaction). The reduction in maternal and perinatal deaths did not differ significantly between the HDP and reference groups. There was a decreased incidence of placental abruption in both HDP and reference groups, which was significantly greater in the HDP than in the reference group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for the interaction). There was also an increased incidence of emergency Cesarean section in both HDP and reference groups; however, this change was significantly greater in the reference than in the HDP group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for the interaction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Following the HYPITAT\u2010I trial, there was a higher rate of induction of labor and improved obstetric outcome in term pregnancies complicated by HDP in The Netherlands. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.20417","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T04:02:17Z","timestamp":1567656137000},"page":"58-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of Hypertension and Preeclampsia Intervention Trial At Near Term\u2010I (HYPITAT\u2010I) on obstetric management and outcome in The Netherlands"],"prefix":"10.1002","volume":"55","author":[{"given":"C. M. W.","family":"de Sonnaville","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, OLVG  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W.","family":"Hukkelhoven","sequence":"additional","affiliation":[{"name":"Perined  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Vlemmix","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Groen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Schutte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Isala Klinieken  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"van Pampus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, OLVG  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.01.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60736-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02710.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2010.486458"},{"key":"e_1_2_7_9_1","unstructured":"National Institute for Health and Clinical Excellence. Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy. NICE: London 2011."},{"key":"e_1_2_7_10_1","unstructured":"American College of Obstetricians and Gynecologists. Task force report \u2018Hypertension in Pregnancy\u2019. ACOG: Washington November 2013."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03138.x"},{"key":"e_1_2_7_12_1","first-page":"CD009273","author":"Cluver C","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20224"},{"key":"e_1_2_7_14_1","unstructured":"Dutch National Perinatal Registry.www.perined.nl[Accessed June 2017]."},{"key":"e_1_2_7_15_1","unstructured":"SwiftE.Promoting normal birth amid modern technology: Opportunities and challenges in Iceland. PhD thesis 2019."},{"key":"e_1_2_7_16_1","first-page":"1","article-title":"Recent declines in induction of labor by gestational age","volume":"155","author":"Osterman MJ","year":"2014","journal-title":"NCHS Data Brief"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01702.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01713.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12950"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2016-000266"},{"key":"e_1_2_7_21_1","first-page":"CD009401","article-title":"Interventions to improve the use of systematic reviews in decision\u2010making by health system managers, policy makers and clinicians","volume":"9","author":"Murthy L","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61998-X"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14987"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.20417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.20417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T10:22:42Z","timestamp":1748514162000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.20417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/uog.20417"],"URL":"https:\/\/doi.org\/10.1002\/uog.20417","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]},"assertion":[{"value":"2019-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}