{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:59:20Z","timestamp":1787795960455,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the diagnostic accuracy of a new ultrasound sign, intracervical lakes (ICL), in predicting the presence of placenta accreta spectrum (PAS) disorder and delivery outcome in patients with placenta previa or low\u2010lying placenta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective multicenter study of women with placenta previa or low\u2010lying placenta at \u2265\u200926\u2009weeks' gestation, who were referred to three Italian tertiary units from January 2015 to September 2018. The presence of ICL, defined as tortuous anechoic spaces within the cervix which appeared to be hypervascular on color Doppler, was evaluated on ultrasound images obtained at the time of referral. The primary aim was to explore the diagnostic accuracy of ICL in detecting the presence and depth of PAS disorder. The secondary aim was to explore the accuracy of this sign in predicting total estimated blood loss, antepartum bleeding, major postpartum hemorrhage at the time of Cesarean section and need for Cesarean hysterectomy. The diagnostic accuracy of ICL in combination with typical sonographic signs of PAS disorder, was assessed by computing summary estimates of sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and diagnostic odds ratios (DOR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 332 women with placenta previa or low\u2010lying placenta were included in the analysis, with a median maternal age of 33.0 (interquartile range, 29.0\u201337.0) years. ICL were noted in 15.1% of patients. On logistic regression analysis, the presence of ICL was associated independently with major postpartum hemorrhage (odds ratio (OR), 3.3 (95%\u2009CI, 1.6\u20136.5); <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), Cesarean hysterectomy (OR, 7.0 (95%\u2009CI, 2.1\u201323.9); <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and placenta percreta (OR, 2.8 (95%\u2009CI, 1.3\u20135.8); <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.01), but not with the presence of any PAS disorder (OR, 1.6 (95%\u2009CI, 0.7\u20133.5); <jats:italic>P<\/jats:italic>\u2009=\u20090.2). Compared with the group of patients without ultrasound signs of PAS disorder, the presence of at least one typical sonographic sign of PAS disorder in combination with ICL had a DOR of 217.2 (95%\u2009CI, 27.7\u20131703.4; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) for placenta percreta and of 687.4 (95%\u2009CI, 121.4\u20133893.0; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) for Cesarean hysterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICL may represent a marker of deep villus invasion in women with suspected PAS disorder on antenatal sonography and anticipate the occurrence of severe maternal morbidity. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.21866","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T14:39:30Z","timestamp":1568126370000},"page":"460-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Intracervical lakes as sonographic marker of placenta accreta spectrum disorder in patients with placenta previa or low\u2010lying placenta"],"prefix":"10.1002","volume":"55","author":[{"given":"E.","family":"di Pasquo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1823-1096","authenticated-orcid":false,"given":"T.","family":"Ghi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cal\u00ec","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Arnas Civico Hospital  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7546-8025","authenticated-orcid":false,"given":"F.","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Hospital of Northern Norway  Troms\u00f8 Norway"},{"name":"Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Science UiT, The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fratelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Forlani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Arnas Civico Hospital  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"F.","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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