{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:39:18Z","timestamp":1789151958320,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2021,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Little is known about cardiac hemodynamics in the fetus with transposition of the great arteries and intact ventricular septum (TGA\u2010IVS). Better understanding of the fetal physiology in TGA\u2010IVS would help to provide insights into specific clinical complications observed after birth, in particular neonatal hypoxia and pulmonary hypertension. The aim of this study was to assess cardiac hemodynamics in fetuses with TGA\u2010IVS by performing systematic longitudinal echocardiographic follow\u2010up from diagnosis to delivery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a longitudinal retrospective study of fetuses referred between 2010 and 2018 to the Sainte\u2010Justine University Hospital Centre. Complete assessment of cardiac hemodynamics was performed in fetuses with TGA\u2010IVS at 18\u201322, 28\u201332 and 35\u201338\u2009weeks' gestation, which were compared with normal fetuses matched for gestational age. The maximum diameter of the foramen ovale was measured using two\u2010dimensional echocardiography under the guidance of color Doppler echocardiography. Fetal cardiac hemodynamics were analyzed according to postnatal preductal transcutaneous oxygen saturation (TcSO\n 2<\/jats:sub>\n ) <\u200965% or \u2265\u200965%, as a neonatal outcome, in fetuses with TGA\u2010IVS.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 59 fetuses with TGA\u2010IVS and 160 normal fetuses were included. Global cardiac output was significantly higher in fetuses with TGA\u2010IVS than in controls, mainly owing to higher global pulmonary output, while global systemic cardiac output did not differ between TGA\u2010IVS fetuses and controls throughout pregnancy. Aortic flow (right ventricular output in fetuses with TGA\u2010IVS, left ventricular output in controls) was significantly higher in fetuses with TGA\u2010IVS than in normal fetuses. Ductal flow was significantly lower in fetuses with TGA\u2010IVS at every timepoint, and this difference increased considerably after 28\u201332\u2009weeks. In parallel, the diameter of the foramen ovale was significantly smaller in fetuses with TGA\u2010IVS at 28\u201332 and 35\u201338\u2009weeks, with a stagnation in growth after 28\u2009weeks, compared with continuous growth in normal fetuses. Most of these cardiac hemodynamic anomalies in fetuses with TGA\u2010IVS were already present at 18\u201322\u2009weeks, and the differences became greater at 28\u201332\u2009weeks' gestation. TGA\u2010IVS neonates with TcSO\n 2<\/jats:sub>\n <\u200965% had lower fetal left ventricular output, higher diastolic ductal retrograde flow and smaller foramen ovale at 28\u201332\u2009weeks, compared with fetal values in those with postnatal TcSO\n 2<\/jats:sub>\n \u2265\u200965%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Compared with normal fetuses, those with TGA\u2010IVS undergo a complex redistribution of blood flow during the second half of pregnancy, with higher global pulmonary flow, lower ductal flow (with negative diastolic flow at the end of pregnancy) and a smaller foramen ovale. In addition, fetal cardiac hemodynamic anomalies observed at 28\u201332\u2009weeks' gestation were associated with lower postnatal TcSO\n 2<\/jats:sub>\n . These observations may provide a better understanding of premature closure of the foramen ovale and postnatal hypoxia that are specific to TGA\u2010IVS physiology. \u00a9 2019 International Society of Ultrasound in Obstetrics and Gynecology\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.21920","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T13:14:05Z","timestamp":1573478045000},"page":"273-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cardiac hemodynamics in fetuses with transposition of the great arteries and intact ventricular septum from diagnosis to end of pregnancy: longitudinal follow\u2010up"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-3399","authenticated-orcid":false,"given":"M.","family":"Lachaud","sequence":"first","affiliation":[{"name":"Department of Fetal and Pediatric Cardiology Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dionne","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston, MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Brassard","sequence":"additional","affiliation":[{"name":"Division of Fetal and Pediatric Cardiology, University of Montreal Sainte\u2010Justine University Hospital Centre Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Charron","sequence":"additional","affiliation":[{"name":"Division of Fetal and Pediatric Cardiology, University of Montreal Sainte\u2010Justine University Hospital Centre Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Birca","sequence":"additional","affiliation":[{"name":"Division of Neurology, University of Montreal Sainte\u2010Justine University Hospital Centre Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dehaes","sequence":"additional","affiliation":[{"name":"Department of Radiology, Radio\u2010oncology and Nuclear Medicine University of Montreal Montreal Quebec Canada"},{"name":"Research Centre Sainte\u2010Justine University Hospital Centre Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010J.","family":"Raboisson","sequence":"additional","affiliation":[{"name":"Division of Fetal and Pediatric Cardiology, University of Montreal Sainte\u2010Justine University Hospital Centre Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.7.916"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1209"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144141.18560.CF"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.12.020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951117000087"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.12.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.09.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17370"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13345"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318030d5b9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007361"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.39.4.536"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.1068"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.3.257"},{"key":"e_1_2_6_17_1","volume-title":"Textbook of Fetal Cardiology","author":"Allan LD","year":"2000"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111200162X"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7474"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.21920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.21920","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.21920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:28:59Z","timestamp":1692862139000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.21920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/uog.21920"],"URL":"https:\/\/doi.org\/10.1002\/uog.21920","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2019-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}