{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:20:50Z","timestamp":1787012450898,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the predictive ability for adverse perinatal outcome of abnormal third\u2010trimester uterine artery Doppler in late small\u2010for\u2010gestational\u2010age (SGA) fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was performed to identify relevant observational studies and randomized controlled trials evaluating the performance of abnormal third\u2010trimester uterine artery Doppler for the prediction of adverse perinatal outcome in suspected SGA fetuses and SGA neonates. Abnormal uterine artery Doppler was defined as uterine artery pulsatility index &gt;\u200995<jats:sup>th<\/jats:sup> percentile or \u2265\u20092\u2009SD above the mean, or bilateral uterine artery notching. Hierarchical summary receiver\u2010operating\u2010characteristics (ROC) curves were constructed using random\u2010effects modeling. Bayesian analysis was used to calculate the posterior probability of adverse perinatal outcome following an abnormal or normal uterine artery Doppler assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen observational studies (including 7552 fetuses either diagnosed with suspected SGA (<jats:italic>n<\/jats:italic>\u2009=\u20093461) or later diagnosed as a SGA neonate (<jats:italic>n<\/jats:italic>\u2009=\u20094091)) met the inclusion criteria; no randomized\u2010controlled trials met the inclusion criteria. Summary ROC curves showed that, among suspected SGA fetuses, the best predictive accuracy of abnormal third\u2010trimester uterine artery Doppler was for perinatal mortality and the worst was for composite adverse perinatal outcome, with areas under the summary ROC curves of 0.90 and 0.66, respectively. The corresponding positive and negative likelihood ratios were 16.5 and 0.6 for perinatal mortality and 2.82 and 0.65 for composite adverse perinatal outcome, respectively. Following an abnormal <jats:italic>vs<\/jats:italic> normal uterine artery Doppler assessment, the posterior risks for composite adverse perinatal outcome, admission to the neonatal intensive care unit, Cesarean section for intrapartum fetal compromise, 5\u2010min Apgar score &lt;\u20097, neonatal acidosis and perinatal death were: 52.3% <jats:italic>vs<\/jats:italic> 20.2%, 48.6% <jats:italic>vs<\/jats:italic> 18.7%, 23.1% <jats:italic>vs<\/jats:italic> 15.2%, 3.59% <jats:italic>vs<\/jats:italic> 1.32%, 9.15% <jats:italic>vs<\/jats:italic> 5.12% and 31.4% <jats:italic>vs<\/jats:italic> 1.64%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal uterine artery Doppler in the third trimester appears to be moderately useful in predicting perinatal death in pregnancies with suspected SGA. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.21940","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:28:34Z","timestamp":1575282514000},"page":"575-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Third\u2010trimester uterine artery Doppler for prediction of adverse outcome in late small\u2010for\u2010gestational\u2010age fetuses: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-3857","authenticated-orcid":false,"given":"R. 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L.","family":"Lip\u2010Sosa","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Center, BCNatal Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia, Obstetricia i Neonatologia, Universitat de Barcelona  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-5596","authenticated-orcid":false,"given":"A.","family":"Sotiriadis","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-1274","authenticated-orcid":false,"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Center, BCNatal Barcelona Center for Maternal\u2010Fetal and 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