{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:51:30Z","timestamp":1789145490721,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/02405"],"award-info":[{"award-number":["PI13\/02405"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the value of the soluble fms\u2010like tyrosine kinase\u20101\/placental growth factor (sFlt\u20101\/PlGF) ratio in predicting the time to delivery in early\u2010onset fetal growth restriction (FGR) with preserved antegrade umbilical artery (UA) flow at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational single\u2010center cohort study of pregnancies with early\u2010onset (&lt;\u200932\u2009+\u20090\u2009weeks) FGR and antegrade UA flow, in which maternal serum sFlt\u20101\/PlGF ratio was determined at diagnosis. FGR was defined as estimated fetal weight &lt;\u20093<jats:sup>rd<\/jats:sup> centile or &lt;\u200910<jats:sup>th<\/jats:sup> centile with UA pulsatility index &gt;\u200995<jats:sup>th<\/jats:sup> centile, fetal middle cerebral artery pulsatility index &lt;\u20095<jats:sup>th<\/jats:sup> centile or cerebroplacental ratio &lt;\u20095<jats:sup>th<\/jats:sup> centile. The previously described sFlt\u20101\/PlGF ratio cut\u2010off value of 85 for facilitating the diagnosis of pre\u2010eclampsia was assessed in the prediction of the need to deliver in &lt;\u20091\u2009week and \u2265\u20094\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 120 cases were included. There were 116 (96.7%) liveborn neonates and 108\u2009(90.0%) perinatal survivors. Median (interquartile range (IQR)) gestational age at diagnosis of early\u2010onset FGR was 27.1\u2009(25.7\u201329.4)\u2009weeks. Median (IQR) sFlt\u20101\/PlGF ratio at diagnosis was 196\u2009(84\u2013474). Ninety (75.0%) cases had a sFlt\u20101\/PlGF ratio \u2265\u200985. Among pregnancies with a liveborn neonate, median (IQR) interval to delivery in the groups with sFlt\u20101\/PlGF ratio &lt;\u200985 and \u2265\u200985 was 41\u2009(22\u201354)\u2009days and 11\u2009(4\u201320)\u2009days, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The probability of having to deliver within 1\u2009week after diagnosis was 0% and 35.6% in those with sFlt\u20101\/PlGF ratio &lt;\u200985 and \u2265\u200985, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), and the probability of delaying delivery for \u2265\u20094\u2009weeks was 72.4% and 19.5%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>sFlt\u20101\/PlGF ratio &lt;\u200985 at diagnosis of early\u2010onset FGR with antegrade UA flow identifies a group of pregnancies in which the need to deliver within 1\u2009week is very low and the interval to delivery is expected to be prolonged for \u2265\u20094\u2009weeks in &gt;\u200970% of cases. Copyright \u00a9 2019 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.21949","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T10:21:37Z","timestamp":1576491697000},"page":"549-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["<scp>sFlt<\/scp>\u20101\/<scp>PlGF<\/scp> ratio and timing of delivery in early\u2010onset fetal growth restriction with antegrade umbilical artery flow"],"prefix":"10.1002","volume":"56","author":[{"given":"M. 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