{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:10:26Z","timestamp":1747152626169,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the risk of small\u2010for\u2010gestational age (SGA) and fetal growth restriction (FGR) and to test the performance of first\u2010trimester screening for SGA and FGR in women with a false\u2010positive high or intermediate risk for aneuploidy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective cohort study of women with a singleton pregnancy attending for a routine first\u2010trimester scan. The risks of aneuploidy and preterm SGA (defined as birth weight &lt;\u200910<jats:sup>th<\/jats:sup> percentile with delivery before 37\u2009weeks) were determined according to Fetal Medicine Foundation algorithms. In non\u2010malformed euploid pregnancies, the predictive performance of both the aneuploidy and preterm SGA risks was evaluated for SGA, FGR (defined as birth weight &lt;\u20093<jats:sup>rd<\/jats:sup> centile), preterm SGA and early SGA (delivery before 34\u2009weeks), using receiver\u2010operating\u2010characteristics (ROC) curve analysis, in those with a high or intermediate risk of aneuploidy and in the overall population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2053 pregnancies were included in the analysis, of which 191 (9.3%) were at high or intermediate risk for aneuploidy (\u2265\u20091\/1000) and 304 (14.8%) were at high risk for preterm SGA (\u2265\u20091\/100). In total, there were 140 (6.8%) cases of SGA, 61 (3.0%) of FGR, 44 (2.1%) of preterm SGA and 33 (1.6%) of early SGA. Among women with a false\u2010positive high or intermediate risk for aneuploidy, the rates of SGA, FGR, preterm SGA and early SGA were 13.6% (26\/191), 7.9 % (15\/191), 6.8% (13\/191) and 5.8% (11\/191), respectively. Compared with women with a first\u2010trimester low risk for preterm SGA, regardless of aneuploidy risk, those with a high risk for preterm SGA and a high or intermediate risk for aneuploidy had relative risks for SGA, FGR, preterm SGA and early SGA of 6 (95%\u2009CI, 3.9\u20139), 9.2 (95%\u2009CI, 5.1\u201316.5), 13.4 (95%\u2009CI, 6.9\u201326.1) and 17.6 (95%\u2009CI, 8.1\u201338.2), respectively. The predictive performance for SGA of the preterm SGA algorithm was higher in women at high or intermediate risk for aneuploidy than in the overall population (area under the ROC curve (AUC), 0.8 <jats:italic>vs<\/jats:italic> 0.7; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Among women at high or intermediate risk for aneuploidy, the predictive performance of the preterm SGA algorithm was better than that of the aneuploidy algorithm for SGA (AUC, 0.80 <jats:italic>vs<\/jats:italic> 0.58; <jats:italic>P<\/jats:italic>\u2009=\u20090.003), preterm SGA (AUC, 0.85 <jats:italic>vs<\/jats:italic> 0.65; <jats:italic>P<\/jats:italic>\u2009=\u20090.013) and early SGA (AUC, 0.86 <jats:italic>vs<\/jats:italic> 0.60; <jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women with a first\u2010trimester false\u2010positive high or intermediate risk of aneuploidy, further screening for SGA allows stratification of the risk for fetal growth disorders. Copyright \u00a9 2020 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.21965","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T10:36:10Z","timestamp":1578393370000},"page":"885-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First\u2010trimester prediction of small\u2010for\u2010gestational age in pregnancies at false\u2010positive high or intermediate risk for fetal aneuploidy"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-1930","authenticated-orcid":false,"given":"T. A.","family":"Yarygina","sequence":"first","affiliation":[{"name":"Federal State Budget Institution \u2018National Research Center for Obstetrics Gynecology and Perinatology named after Academician V.I.Kulakov\u2019 Ministry of Healthcare of the Russian Federation  Moscow Russian Federation"},{"name":"Perinatal Cardiology Center of Federal State Budget Institution \u2018A.N. Bakulev National Medical Research Center of Cardiovascular Surgery\u2019 of the Ministry of Health of the Russian Federation  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Bataeva","sequence":"additional","affiliation":[{"name":"Russian Medical Academy of Continuous Professional Education  Moscow Russian Federation"},{"name":"Fetal Medicine Centre Medica  Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-036X","authenticated-orcid":false,"given":"L.","family":"Benitez","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-1274","authenticated-orcid":false,"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"Fetal i+D Fetal Medicine Research Center, BCNatal\u00a0\u2013\u00a0Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), IDIBAPS University of Barcelona, and Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.01.032"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001406"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17283"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357430"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1860"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9075"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15783"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00108-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diapre.2013.06.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-015-0826-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000145"},{"key":"e_1_2_6_13_1","first-page":"281","article-title":"Correlation of pregnancy outcome with quadruple screening test at second trimester","volume":"29","author":"Yazdani S","year":"2015","journal-title":"Med J Islam Repub Iran"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20282"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1806"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f108"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.09.076"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341712"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12537"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15879"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15919"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60932-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6366"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264259"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-947164"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.06.021"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3469-0"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5165"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0230"},{"volume-title":"RCOG Green\u2010Top Guidline No. 31. 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