{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:10:27Z","timestamp":1747152627156,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) may contribute to the pathogenesis of pre\u2010eclampsia (PE), but their role remains to be elucidated. Our aims were to evaluate the surrogates of AVP and ANP, C\u2010terminal pro\u2010AVP (copeptin) and mid\u2010regional pro\u2010ANP (MR\u2010proANP), as biomarkers for the prediction of PE\u2010related pregnancy complications and whether they are associated with angiogenic markers and\/or clinical manifestations of PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of a prospective cohort study that enrolled pregnant women with suspected or confirmed PE, between December 2013 and April 2016. From each patient, a blood sample was obtained at study entry and serum levels of copeptin, MR\u2010proANP, soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and placental growth factor (PlGF) were measured. We evaluated the ability of sFlt\u20101, PlGF, sFlt\u20101\/PlGF ratio, copeptin and MR\u2010proANP, assessed either alone or combined with traditional predictors (gestational age, parity, diastolic blood pressure and proteinuria), to predict maternal complications and fetal\/neonatal complications. Models were compared using concordance statistic (C\u2010index).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 526 women were evaluated in the study. Women with confirmed PE displayed elevated serum copeptin and MR\u2010proANP levels in comparison to those with suspected PE but no hypertensive disease of pregnancy. When combined with traditional predictors, the sFlt\u20101\/PlGF ratio displayed a higher C\u2010index than copeptin and MR\u2010proANP (0.76, 0.63 and 0.67, respectively, <jats:italic>vs<\/jats:italic> 0.60 for the traditional predictors alone) for the prediction of maternal complications. Similarly, for the prediction of fetal\/neonatal complications, the sFlt\u20101\/PlGF ratio displayed a higher C\u2010index than copeptin and MR\u2010proANP when added to the traditional model (0.83, 0.79 and 0.80, respectively, <jats:italic>vs<\/jats:italic> 0.79 for the traditional predictors alone). When subdividing women according to sFlt\u20101\/PlGF ratio (\u2265\u200985 <jats:italic>vs<\/jats:italic> &lt;\u200985), no differences in copeptin levels were observed, while MR\u2010proANP level was elevated in women with sFlt\u20101\/PlGF ratio \u2265\u200985. Multiple regression analysis revealed that copeptin and MR\u2010proANP were independent determinants of proteinuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Copeptin and MR\u2010proANP have limited value in predicting PE\u2010related complications when compared with the sFlt\u20101\/PlGF ratio. However, both copeptin and MR\u2010proANP were associated with proteinuria, with copeptin exerting this effect independently of the sFlt\u20101\/PlGF ratio. Copyright \u00a9 2020 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.21979","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T09:46:09Z","timestamp":1579859169000},"page":"872-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Copeptin and mid\u2010regional pro\u2010atrial natriuretic peptide in women with suspected or confirmed pre\u2010eclampsia: comparison with sFlt\u20101\/PlGF ratio"],"prefix":"10.1002","volume":"56","author":[{"given":"R. I.","family":"Neuman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Pharmacology and Vascular Medicine Erasmus Medical Center  Rotterdam The\u00a0Netherlands"},{"name":"Department of Obstetrics and Gynecology, Division Obstetrics and Prenatal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M. Alblas","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-3109","authenticated-orcid":false,"given":"L.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pharmacology and Vascular Medicine Erasmus Medical Center  Rotterdam The\u00a0Netherlands"},{"name":"Department of Obstetrics and Gynecology, Division Obstetrics and Prenatal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A. A.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"van den Meiracker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pharmacology and Vascular Medicine Erasmus Medical Center  Rotterdam The\u00a0Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H. J.","family":"Danser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pharmacology and Vascular Medicine Erasmus Medical Center  Rotterdam The\u00a0Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pharmacology and Vascular Medicine Erasmus Medical Center  Rotterdam The\u00a0Netherlands"},{"name":"Department of Obstetrics and Gynecology, Division Obstetrics and Prenatal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000419"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0232"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.185264"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01498.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000361016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03848"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03762"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09913"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152635"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-0110"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01787"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90776-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00073.2015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.08.012"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3745-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19040"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0939"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09256"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99403"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05267"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.21979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.21979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.21979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.21979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:58:08Z","timestamp":1693191488000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.21979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/uog.21979"],"URL":"https:\/\/doi.org\/10.1002\/uog.21979","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"type":"print","value":"0960-7692"},{"type":"electronic","value":"1469-0705"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2019-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}