{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:30:25Z","timestamp":1793737825010,"version":"4.6.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Congenital diaphragmatic hernia (CDH) can cause a significant mass effect in the fetal thorax, displacing the heart into the opposite hemithorax. In left\u2010sided CDH (L\u2010CDH), this is associated with smaller left\u2010sided cardiac structures and reduced left\u2010ventricular cardiac output (LVCO). The effect of these physiologic changes on cerebral blood flow is not well understood. We sought to describe the middle cerebral artery (MCA) pulsatility index (PI), a measure of cerebrovascular impedance, in fetuses with L\u2010CDH and those with right\u2010sided CDH (R\u2010CDH) compared with unaffected fetuses, and the relationship between MCA\u2010PI and LVCO. We hypothesized that MCA\u2010PI would be lower in fetuses with L\u2010CDH and similar in those with R\u2010CDH compared to controls, and that MCA\u2010PI would be correlated with LVCO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We identified all fetuses with CDH evaluated at The University of California San Francisco, San Francisco, CA, USA from 2011 to 2018. Fetal echocardiograms and ultrasound scans were reviewed. Umbilical artery and MCA Doppler examinations were assessed to calculate pulsatility indices. Ventricular outputs were calculated using Doppler\u2010derived stroke volume and fetal heart rate. Lung\u2010to\u2010head ratio (LHR), estimated fetal weight, biparietal diameter (BPD) and head circumference (HC) were obtained from fetal sonograms. Measurements in fetuses with CDH, according to the side of the defect, were compared with those in unaffected, gestational age\u2010matched controls. A subset of CDH survivors had available data on neurodevelopmental outcome, as assessed using the Bayley Scales of Infant Development, 3\n                      <jats:sup>rd<\/jats:sup>\n                      edition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 64 fetuses with CDH (L\u2010CDH,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953; R\u2010CDH,\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200911) comprised the study groups, with 27 unaffected fetuses serving as controls. Mean gestational age at evaluation was similar between the three groups. Compared to controls, fetuses with L\u2010CDH had significantly lower LVCO expressed as a percentage of combined cardiac output (CCO) (32%; 95%\u2009CI, 29\u201335%\n                      <jats:italic>vs<\/jats:italic>\n                      38%; 95%\u2009CI, 33\u201342%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04) and lower MCA\u2010PI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score (\u22121.3; 95%\u2009CI, \u22121.7 to \u22121.0\n                      <jats:italic>vs<\/jats:italic>\n                      0.08; 95%\u2009CI, \u22120.5 to 0.6;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), while they did not differ between the R\u2010CDH group and controls. There was a strong positive association between LVCO as a percentage of CCO and MCA\u2010PI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score in the overall cohort of CDH and control fetuses (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). BPD and HC were similar between the three groups. At neurodevelopmental follow\u2010up, mean cognitive, motor and language scores in the CDH group were within 1\u2009SD of those in the general population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCA\u2010PI values are significantly lower in fetuses with L\u2010CDH as compared to controls, and lower LVCO was correlated with lower MCA vascular impedance. The neurodevelopmental effect of changes in MCA\u2010PI in response to decreased LVCO is unknown, although, on average, CDH survivors had neurodevelopmental scores in the normal range. This may reflect a fetal compensatory mechanism in response to diminished antegrade cerebral blood flow. \u00a9 2020 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.21992","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T11:37:58Z","timestamp":1582025878000},"page":"386-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Fetal cerebrovascular impedance is reduced in left congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-6695","authenticated-orcid":false,"given":"K. A.","family":"Kosiv","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics The University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-693X","authenticated-orcid":false,"given":"A.","family":"Moon\u2010Grady","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics The University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1765-0213","authenticated-orcid":false,"given":"W.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics The University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Keller","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics The University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics The University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics The University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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