{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:38Z","timestamp":1786978598125,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To illustrate the prenatal cerebral imaging features associated with tubulinopathy, we report on five affected fetuses from unrelated families, with a\n                    <jats:italic>de\u2010novo<\/jats:italic>\n                    heterozygous variant in a tubulin gene (\n                    <jats:italic>TUBA1A<\/jats:italic>\n                    ,\n                    <jats:italic>TUBB2B<\/jats:italic>\n                    or\n                    <jats:italic>TUBB3<\/jats:italic>\n                    ). We identified two distinct prenatal imaging patterns related to tubulinopathy: a severe form, characterized by enlarged germinal matrices, microlissencephaly and a kinked brainstem; and a mild form which has not been reported previously in the prenatal literature. The latter form is associated with non\u2010specific features, including an asymmetric brainstem, corpus callosal dysgenesis, a lack of Sylvian fissure operculization and distortion of the anterior part of the interhemispheric fissure with subsequent impacted medial borders of the frontal lobes, the combination of which, in the absence of additional extracerebral anomalies, is highly suggestive of tubulinopathy. Copyright \u00a9 2020 ISUOG. Published by John Wiley &amp; Sons Ltd.\n                  <\/jats:p>","DOI":"10.1002\/uog.22010","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T07:40:05Z","timestamp":1583739605000},"page":"493-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Two different prenatal imaging cerebral patterns of tubulinopathy"],"prefix":"10.1002","volume":"57","author":[{"given":"S.","family":"Cabet","sequence":"first","affiliation":[{"name":"Imagerie P\u00e9diatrique et F\u0153tale, H\u00f4pital Femme M\u00e8re Enfant Universit\u00e9 Claude Bernard Lyon 1  Lyon\u2010Bron France"},{"name":"Service de G\u00e9n\u00e9tique Groupement Hospitalier Est, Universit\u00e9 Claude Bernard Lyon 1  Lyon\u2010Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Karl","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis Munich  Munich Germany"},{"name":"Department of Obstetrics and Gynecology University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Imaging H\u00f4pital d'Enfants Armand\u2010Trousseau APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Delius","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hartung","sequence":"additional","affiliation":[{"name":"Office of Prenatal Diagnosis  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lesca","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique Groupement Hospitalier Est, Universit\u00e9 Claude Bernard Lyon 1  Lyon\u2010Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9089-7119","authenticated-orcid":false,"given":"R.","family":"Chaoui","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-6654","authenticated-orcid":false,"given":"L.","family":"Guibaud","sequence":"additional","affiliation":[{"name":"Imagerie P\u00e9diatrique et F\u0153tale, H\u00f4pital Femme M\u00e8re Enfant Universit\u00e9 Claude Bernard Lyon 1  Lyon\u2010Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.10.003"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-69"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2015.05.006"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5589"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu082"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12141"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5610-0"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12498"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4945-2"}],"container-title":["Ultrasound in Obstetrics &amp; 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