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Univariate and two\u2010level multivariable logistic regression analyses were used to assess the association of ARED in the umbilical artery, as compared with normal or reduced end\u2010diastolic flow, with severe or moderate neuromotor and\/or sensory disability and with an Ages and Stages Questionnaire (ASQ) score below a threshold. This was defined as a score more than 2 SD below the mean in any of the five domains, at age 2, adjusting for gestational age at delivery. ASQ is used to identify children at risk of developmental delay requiring reinforced follow\u2010up and further evaluation. Descriptive statistics and bivariate tests were weighted according to the duration of the inclusion periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 484 children followed up at 2\u2009years of age, for whom prenatal umbilical artery Doppler ultrasound was available. Among them, 8\/484 (1.6%) had severe or moderate neuromotor and\/or sensory disability, and 156\/342 (45.4%) had an ASQ score below the threshold. Compared with normal or reduced end\u2010diastolic flow in the umbilical artery (<jats:italic>n<\/jats:italic>\u2009=\u2009305), ARED (<jats:italic>n<\/jats:italic>\u2009=\u2009179) was associated with severe or moderate neuromotor and\/or sensory disability (adjusted odds ratio (OR), 11.3; 95%\u2009CI, 1.4\u201393.2) but not with an ASQ score below the threshold (adjusted OR, 1.2; 95%\u2009CI, 0.8\u20131.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among children delivered before 32\u2009weeks of gestation due to suspected FGR and\/or maternal hypertensive disorder who survived until 2\u00a0years of age, prenatal ARED in the umbilical artery was associated with a higher incidence of severe or moderate neuromotor and\/or sensory disability. Copyright \u00a9 2020 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.22025","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T18:24:01Z","timestamp":1585160641000},"page":"557-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neurodevelopment at 2\u2009years and umbilical artery Doppler in cases of very preterm birth after prenatal hypertensive disorder or suspected fetal growth restriction:<scp>EPIPAGE<\/scp>\u20102 prospective population\u2010based cohort study"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-9161","authenticated-orcid":false,"given":"P.","family":"Delorme","sequence":"first","affiliation":[{"name":"INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Center for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS) FHU PREMA Paris Descartes University Paris France"},{"name":"Sorbonne Universit\u00e9 AP\u2010HP, Department of Gynaecology and Obstetrics, Trousseau Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kayem","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Center for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS) FHU PREMA Paris Descartes University Paris France"},{"name":"Sorbonne Universit\u00e9 AP\u2010HP, Department of Gynaecology and Obstetrics, Trousseau Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lorthe","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Center for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS) FHU PREMA Paris Descartes University Paris France"},{"name":"EPIUnit\u00a0\u2013\u00a0Instituto de Sa\u00fade P\u00fablica Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sentilhes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Bordeaux University Hospital Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zeitlin","sequence":"additional","affiliation":[{"name":"INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Center for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS) FHU PREMA Paris Descartes University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Subtil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, CHU Lille, Hop Jeanne de Flandre EA 2694\u00a0\u2013\u00a0Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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