{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:43:10Z","timestamp":1793497390976,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the ultrasound features of different endometrial and other intracavitary pathologies inpre\u2010 and postmenopausal women presenting with abnormal uterine bleeding, using the International Endometrial Tumor Analysis (IETA) terminology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective observational multicenter study of consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler and fluid\u2010instillation sonography were performed. Endometrial sampling was performed according to each center's local protocol. The histological endpoints were cancer, atypical endometrial hyperplasia\/endometrioid intraepithelial neoplasia (EIN), endometrial atrophy, proliferative or secretory endometrium, endometrial hyperplasia without atypia, endometrial polyp, intracavitary leiomyoma and other. For fluid\u2010instillation sonography, the histological endpoints were endometrial polyp, intracavitary leiomyoma and cancer. For each histological endpoint, we report typical ultrasound features using the IETA terminology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The database consisted of 2856 consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler was performed in all cases and fluid\u2010instillation sonography in 1857. In 2216 women, endometrial histology was available, and these comprised the study population. Median age was 49\u2009years (range, 19\u201392\u2009years), median parity was 2 (range, 0\u201310) and median body mass index was 24.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (range, 16.0\u201372.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Of the study population, 843 (38.0%) women were postmenopausal. Endometrial polyps were diagnosed in 751  (33.9%) women, intracavitary leiomyomas in 223 (10.1%) and endometrial cancer in 137 (6.2%). None (0% (95%\u2009CI, 0.0\u20135.5%)) of the 66 women with endometrial thickness &lt;\u20093\u2009mm had endometrial cancer or atypical hyperplasia\/EIN. Endometrial cancer or atypical hyperplasia\/EIN was found in three of 283 (1.1% (95%\u2009CI, 0.4\u20133.1%)) endometria with a three\u2010layer pattern, in three of 459 (0.7% (95%\u2009CI, 0.2\u20131.9%)) endometria with a linear endometrial midline and in five of 337 (1.5% (95%\u2009CI, 0.6\u20133.4%)) cases with a single vessel without branching on unenhanced ultrasound.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The typical ultrasound features of endometrial cancer, polyps, hyperplasia and atrophy and intracavitary leiomyomas,  are described using the IETA terminology. The detection of some easy\u2010to\u2010assess IETA features (i.e. endometrial thickness &lt;\u20093\u2009mm, three\u2010layer pattern, linear midline and single vessel without branching) makes endometrial cancer unlikely. Copyright \u00a9 2020 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.22109","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T07:44:05Z","timestamp":1591083845000},"page":"164-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (\n                    <scp>IETA<\/scp>\n                    ) terminology in women with abnormal uterine bleeding"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-5036","authenticated-orcid":false,"given":"T.","family":"Van Den Bosch","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Development and Regeneration KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-7211","authenticated-orcid":false,"given":"J. Y.","family":"Verbakel","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-6414","authenticated-orcid":false,"given":"L.","family":"Valentin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital, Malm\u00f6  Sweden"},{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wynants","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration KU Leuven  Leuven Belgium"},{"name":"Department of Epidemiology, CAPHRI Care and Public Health Research Institute Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"De Cock","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-6981","authenticated-orcid":false,"given":"M. A.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproduction Hospital Universitario Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. P. G.","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Sciences Institute L. Sacco University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-8135","authenticated-orcid":false,"given":"P.","family":"Sladkevicius","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital, Malm\u00f6  Sweden"},{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-0853","authenticated-orcid":false,"given":"J. L.","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Clinica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Votino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fruscio","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynecology University of Milan\u2010Bicocca, San Gerardo Hospital  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lanzani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Sciences Institute L. 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