{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:54:15Z","timestamp":1783072455360,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the morbidity and mortality of neonates with left\u2010sided isolated congenital diaphragmatic hernia (CDH) according to gestational age at delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of fetuses diagnosed prenatally with isolated left\u2010sided CDH that were delivered in the University Hospitals of Antoine B\u00e9cl\u00e8re\u2010Bic\u00eatre and Leuven between 1 January 2010 and 31 December 2018. The Kaplan\u2013Meier method was used to calculate cumulative survival at 28\u2009days after birth according to gestational age at delivery. The association between gestational age at delivery, as a continuous variable, and survival at 28\u2009days was modeled using a fractional polynomial. Adjustment for position of the liver, management center and mode of delivery was performed. The association was also evaluated according to the severity of CDH, as defined by the observed\u2010to\u2010expected lung\u2010to\u2010head ratio (o\/e\u2010LHR), which was classified as severe (o\/e\u2010LHR &lt;\u200925%), moderate (o\/e\u2010LHR between 25% and 45%) or mild (o\/e\u2010LHR &gt;\u200945%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 213 fetuses with isolated left\u2010sided CDH, with a median gestational age at delivery of 38\u2009+\u20092\u2009weeks (interquartile range, 37\u2009+\u20090 to 39\u2009+\u20091\u2009weeks). The survival rates at 28\u2009days and at 6\u2009months were 66.7% (142\/213) and 64.3% (137\/213), respectively. Kaplan\u2013Meier analysis showed a higher survival rate at 28\u2009days for babies delivered between 37\u2009+\u20090 and 38\u2009+\u20096\u2009weeks than for those delivered at or after 39\u2009+\u20090\u2009weeks (log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the subgroup of moderate CDH, the 28\u2010day survival rate was significantly higher in newborns delivered between 37\u2009+\u20090 and 38\u2009+\u20096\u2009weeks than in those delivered at or after 39\u2009+\u20090\u2009weeks (81.5% <jats:italic>vs<\/jats:italic> 61.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.03), and this was also the case for survival rate at 6\u2009months. In the subgroup with moderate CDH, 28\u2010day survival significantly increased with advancing gestational age at birth up to about 38\u201339\u2009weeks (<jats:italic>P<\/jats:italic>\u2009=\u20090.005), and significantly decreased from 39\u2009weeks onwards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Delivery between 37\u2009+\u20090 and 38\u2009+\u20096\u2009weeks\u2019 gestation is associated with a higher survival rate at 28\u2009days in neonates with isolated left\u2010sided CDH and moderate lung hypoplasia, independently of intrathoracic liver, management center and mode of delivery. \u00a9 2020 International Society of Ultrasound in Obstetrics and Gynecology<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.22133","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T23:54:22Z","timestamp":1593647662000},"page":"968-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Optimal gestational age at delivery in isolated left\u2010sided congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-2815","authenticated-orcid":false,"given":"H.","family":"Bouchghoul","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Assistance Publique\u2010H\u00f4pitaux de Paris, Bic\u00eatre Hospital University Paris\u2010Saclay, Le Kremlin\u2010Bic\u00eatre  France"},{"name":"Centre Reference Maladie Rare, Hernie de Coupole Diaphragmatique  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Dumery","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Assistance Publique\u2010H\u00f4pitaux de Paris, Bic\u00eatre Hospital University Paris\u2010Saclay, Le Kremlin\u2010Bic\u00eatre  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M.","family":"Russo","sequence":"additional","affiliation":[{"name":"Clinical Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Academic Department of Development and Regeneration, Cluster Woman and Child KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6006-8408","authenticated-orcid":false,"given":"A. G.","family":"Cordier","sequence":"additional","affiliation":[{"name":"Centre Reference Maladie Rare, Hernie de Coupole Diaphragmatique  Clamart France"},{"name":"Department of Obstetrics and Gynecology, Assistance Publique\u2010H\u00f4pitaux de Paris, Antoine B\u00e9cl\u00e8re Hospital University Paris\u2010Saclay  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Le Sache","sequence":"additional","affiliation":[{"name":"Centre Reference Maladie Rare, Hernie de Coupole Diaphragmatique  Clamart France"},{"name":"Department of Neonatology, Assistance Publique\u2010H\u00f4pitaux de Paris, Bic\u00eatre Hospital University Paris\u2010Saclay, Le Kremlin\u2010Bic\u00eatre  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Debeer","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Decaluwe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Fouquet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, H\u00f4pital Bic\u00eatre, Assistance Publique\u2010H\u00f4pitaux de Paris University Paris\u2010Saclay, Le Kremlin\u2010Bic\u00eatre  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Senat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Assistance Publique\u2010H\u00f4pitaux de Paris, Bic\u00eatre Hospital University Paris\u2010Saclay, Le Kremlin\u2010Bic\u00eatre  France"},{"name":"Centre Reference Maladie Rare, Hernie de Coupole Diaphragmatique  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"J.","family":"Deprest","sequence":"additional","affiliation":[{"name":"Clinical Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Academic Department of Development and Regeneration, Cluster Woman and Child KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Benachi","sequence":"additional","affiliation":[{"name":"Centre Reference Maladie Rare, Hernie de Coupole Diaphragmatique  Clamart France"},{"name":"Department of Obstetrics and Gynecology, Assistance Publique\u2010H\u00f4pitaux de Paris, Antoine B\u00e9cl\u00e8re Hospital University Paris\u2010Saclay  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30201-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306174"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.02.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2108-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.01.049"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.01.073"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12445"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.12.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0528"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320622"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2651"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.03.018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.08.026"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6141"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800566"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5401"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.221"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480451"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5297"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1106"}],"container-title":["Ultrasound in Obstetrics &amp; 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