{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:36:08Z","timestamp":1773156968050,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether repeat cervical\u2010length (CL) measurement in women discharged from hospital after their first episode of threatened preterm labor can predict their risk of spontaneous preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a secondary analysis of a randomized controlled trial of maintenance tocolysis, in which CL was measured on transvaginal ultrasound at the time of hospital discharge and after 2, 4, 8 and 12\u2009weeks, in women who remained undelivered after their first episode of threatened preterm labor. After univariate analysis, multivariate logistic regression analysis was used to assess whether CL &lt;\u200910\u2009mm at the time of hospital discharge or at any follow\u2010up evaluation could predict spontaneous delivery prior to 37\u2009weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 226 women discharged after a diagnosis of threatened preterm labor, 57 (25.2%) delivered spontaneously prior to 37\u2009weeks' gestation. The risk of spontaneous preterm birth was higher among women with CL &lt;\u200910\u2009mm at hospital discharge compared to those with CL \u2265\u200910\u2009mm (adjusted odds ratio (aOR), 3.3; 95%\u2009CI, 1.2\u20139.2). Moreover, spontaneous preterm delivery was more common when CL &lt;\u200910\u2009mm was detected up to 2\u2009weeks (aOR, 2.9; 95%\u2009CI, 1.1\u20137.3) or up to 4\u2009weeks (aOR, 7.3; 95%\u2009CI, 2.3\u201322.8) post discharge, as compared with when CL was persistently \u2265\u200910\u2009mm. The association was not significant when considering CL measurements at 8\u2009weeks, and there was insufficient information to assess the effect of measurements obtained at 12\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women who remain undelivered after their first episode of threatened preterm labor continue to be at high risk of spontaneous preterm birth if their CL is below 10\u2009mm at the time of hospital discharge or at any follow\u2010up visit up to 4\u2009weeks later. CL measurement could be included in the antenatal care of these women in order to stratify their risk of preterm birth, rationalize resource utilization and help clinicians improve pregnancy outcome. \u00a9 2020 International Society of Ultrasound in Obstetrics and Gynecology<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.22188","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T17:20:10Z","timestamp":1599067210000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serial cervical\u2010length measurements after first episode of threatened preterm labor improve prediction of spontaneous delivery prior to 37\u2009weeks' gestation"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-3652","authenticated-orcid":false,"given":"G.","family":"Chiossi","sequence":"first","affiliation":[{"name":"Division of Obstetrics, Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Division of Obstetrics, Department of Medical and Surgical Sciences for Mother, Child and Adult University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vergani","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Obstetrics and Gynecology Branch University of Milano\u2010Bicocca Health Science  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Di Tommaso","sequence":"additional","affiliation":[{"name":"Health Science Department, Obstetrics and Gynecology Branch University of Florence  Florence 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Public Health University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PROTECT Collaborative Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61856-X"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Deaths: final data for 2017","volume":"68","author":"Kochanek KD","year":"2019","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050435"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7457"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17388"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002065"},{"key":"e_1_2_6_8_1","unstructured":"[Management of spontaneous preterm birth 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