{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:46:36Z","timestamp":1782747996364,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U01\u2010087177\u201001"],"award-info":[{"award-number":["U01\u2010087177\u201001"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the feasibility of using umbilical artery (UA) Doppler waveforms to measure fetal heart rate (FHR) short\u2010term variation (STV) across gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective longitudinal study, conducted at two study sites, of 195 pregnancies considered low risk. Pulsed\u2010wave Doppler of the UAs was performed at 4\u2010weekly intervals, between 14 and 40\u2009weeks of gestation, using a standardized imaging protocol. Up to 12 consecutive UA Doppler waveforms were analyzed using offline processing software. FHR STV was calculated using average R\u2013R intervals extracted from the waveforms and baseline corrected for FHR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline\u2010corrected FHR STV increased significantly with gestational age (conditional\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.37;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and was correlated inversely with FHR (conditional\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.54;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The STV ranged (median (interquartile range)) from 3.5 (2.9\u20134.1) ms at 14\u201320\u2009weeks' gestation to 6.3 (4.8\u20137.7) ms at 34\u201340\u2009weeks' gestation. The change in heart rate STV did not differ between study sites or individual sonographers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UA Doppler waveforms offer a robust and feasible method to derive STV of the FHR. It should be emphasized that the UA Doppler\u2010derived STV is not interchangeable with measurements derived with computerized cardiotocography. Accordingly, further investigations are needed to validate associations with outcome, in order to determine the value of concurrent fetal cardiovascular and heart rate evaluations that are possible with the technique described here. \u00a9 2020 International Society of Ultrasound in Obstetrics and Gynecology<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.23145","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T14:16:19Z","timestamp":1602166579000},"page":"70-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Determination of fetal heart rate short\u2010term variation from umbilical artery Doppler waveforms"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-8564","authenticated-orcid":false,"given":"L. S.","family":"Cahill","sequence":"first","affiliation":[{"name":"Mouse Imaging Centre The Hospital for Sick Children  Toronto ON Canada"},{"name":"Department of Chemistry Memorial University of Newfoundland, St John's, Newfoundland and Labrador  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Stortz","sequence":"additional","affiliation":[{"name":"Translational Medicine The Hospital for Sick Children  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ravi Chandran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Milligan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Paediatrics The Hospital for Sick Children  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shinar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital  Toronto ON Canada"},{"name":"Pregnancy Research Centre, Department of Obstetrics and Gynaecology Royal Women's Hospital  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Millard","sequence":"additional","affiliation":[{"name":"Centre for Fetal Therapy Johns Hopkins Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Macgowan","sequence":"additional","affiliation":[{"name":"Translational Medicine The Hospital for Sick Children  Toronto ON Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Kingdom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital  Toronto ON Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-283X","authenticated-orcid":false,"given":"J. G.","family":"Sled","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre The Hospital for Sick Children  Toronto ON Canada"},{"name":"Translational Medicine The Hospital for Sick Children  Toronto ON Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto ON Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-2084","authenticated-orcid":false,"given":"A. A.","family":"Baschat","sequence":"additional","affiliation":[{"name":"Centre for Fetal Therapy Johns Hopkins Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"CD007863","article-title":"Antenatal cardiotocography for fetal assessment","volume":"12","author":"Grivell RM","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122447"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17215"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.01.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21887"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357592"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e35"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.3004511"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00134.x"},{"key":"e_1_2_8_13_1","first-page":"259","article-title":"An open\u2010source algorithm to detect onset of arterial blood pressure pulses","volume":"30","author":"Zong W","year":"2003","journal-title":"Comput Cardiol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6365"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2016-0065"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1996.24.1.25"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199905)34:2<257::AID-DEV2>3.0.CO;2-V"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/30\/2\/008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2004.06.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13190"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.23145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:19:42Z","timestamp":1782746382000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.23145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/uog.23145"],"URL":"https:\/\/doi.org\/10.1002\/uog.23145","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,3]]},"assertion":[{"value":"2020-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}