{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:46:43Z","timestamp":1782748003028,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Type\u2010III selective intrauterine growth restriction (sIUGR) is associated with a high and unpredictable risk of fetal death and fetal brain injury. The objective of this study was to describe the prospective risk of fetal death and the risk of adverse neonatal outcome in a cohort of twin pregnancies complicated by Type\u2010III sIUGR and treated according to up\u2010to\u2010date guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed retrospectively all monochorionic diamniotic twin pregnancies complicated by Type\u2010III sIUGR managed at nine fetal centers over a 12\u2010year period. Higher\u2010order multiple gestations and pregnancies with major fetal anomalies or other monochorionicity\u2010related complications at initial presentation were excluded. Data on fetal and neonatal outcomes were collected and management strategies reviewed. Composite adverse neonatal outcome was defined as neonatal death, invasive ventilation beyond the resuscitation period, culture\u2010proven sepsis, necrotizing enterocolitis requiring treatment, intraventricular hemorrhage Grade &gt;\u2009I, retinopathy of prematurity Stage &gt;\u2009II or cystic periventricular leukomalacia. The prospective risk of intrauterine death (IUD) and the risk of neonatal complications according to gestational age were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We collected data on 328 pregnancies (656 fetuses). After exclusion of pregnancies that underwent selective reduction (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018 (5.5%)), there were 51\/620 (8.2%) non\u2010iatrogenic IUDs in 35\/310 (11.3%) pregnancies. Single IUD occurred in 19\/328 (5.8%) pregnancies and double IUD in 16\/328 (4.9%). The prospective risk of non\u2010iatrogenic IUD per fetus declined from 8.1% (95%\u2009CI, 5.95\u201310.26%) at 16\u2009weeks, to less than 2% (95%\u2009CI, 0.59\u20132.79%) after 28.4\u2009weeks and to less than 1% (95%\u2009CI, \u20130.30 to 1.89%) beyond 32.6\u2009weeks. In otherwise uncomplicated pregnancies with Type\u2010III sIUGR, delivery was generally planned at 32\u2009weeks, at which time the risk of composite adverse neonatal outcome was 29.0% (31\/107 neonates). In twin pregnancies that continued to 34\u2009weeks, there was a very low risk of IUD (0.7%) and a low risk of composite adverse neonatal outcome (11%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cohort of twin pregnancies complicated by Type\u2010III sIUGR and treated at several tertiary fetal centers, the risk of fetal death was lower than that reported previously. Further efforts should be directed at identifying predictors of fetal death and optimal antenatal surveillance strategies to select a cohort of pregnancies that can continue safely beyond 33\u2009weeks' gestation. \u00a9 2020 International Society of Ultrasound in Obstetrics and Gynecology<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.23515","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T13:11:00Z","timestamp":1603113060000},"page":"126-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Outcome of monochorionic twin pregnancy complicated by\n                    <scp>Type\u2010III<\/scp>\n                    selective intrauterine growth restriction"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-4846","authenticated-orcid":false,"given":"S.","family":"Shinar","sequence":"first","affiliation":[{"name":"Ontario Fetal Centre, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Xing","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit &amp;Prenatal Diagnosis Center Shanghai 1st Maternity and Infant Hospital of Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Pruthi","sequence":"additional","affiliation":[{"name":"Ontario Fetal Centre, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jianping","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit &amp;Prenatal Diagnosis Center Shanghai 1st Maternity and Infant Hospital of Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Slaghekke","sequence":"additional","affiliation":[{"name":"Department of Gynecology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Groene","sequence":"additional","affiliation":[{"name":"Department of Gynecology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-5778","authenticated-orcid":false,"given":"L.","family":"Lewi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-7151","authenticated-orcid":false,"given":"I.","family":"Couck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-370X","authenticated-orcid":false,"given":"Y.","family":"Yinon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Batsry","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-3810","authenticated-orcid":false,"given":"L.","family":"Raio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Inselspital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Amylidi\u2010Mohr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Inselspital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-6496","authenticated-orcid":false,"given":"D.","family":"Baud","sequence":"additional","affiliation":[{"name":"Department of Woman\u2010Mother\u2010Child Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kneuss","sequence":"additional","affiliation":[{"name":"Department of Woman\u2010Mother\u2010Child Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Dekoninck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Moscou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre University of Toronto  Toronto ON 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