{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:23:31Z","timestamp":1768008211537,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91859115"],"award-info":[{"award-number":["91859115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Transperineal ultrasound is a simple and highly repeatable method that has been used increasingly in the quantification of pelvic organ prolapse, but abnormal uterine descent on ultrasound in Chinese women is still poorly defined. We aimed to determine the optimal cut\u2010off to define abnormal uterine descent on transperineal ultrasound in Chinese women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective multicenter study recruited women who were examined in tertiary\u2010level gynecological centers, due to symptoms of lower urinary tract and\/or pelvic floor dysfunction, between February 2017 and September 2018. All recruited women underwent a standardized interview, pelvic organ prolapse quantification (POP\u2010Q) examination, and four\u2010dimensional transperineal ultrasound examination. On ultrasound, uterine descent was measured relative to the posteroinferior margin of the symphysis pubis during maximum Valsalva maneuver. The optimal cut\u2010off value for definition of abnormal uterine descent was selected as the value with the highest Youden index and the diagnostic performance of this cut\u2010off for the prediction of prolapse symptoms and POP\u2010Q stage was assessed and compared by means of the area under the receiver\u2010operating\u2010characteristics curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 538 Chinese women, with a mean age of 39.4 (range, 18\u201381)\u2009years, were enrolled into the study. Both uterine descent on transperineal ultrasound (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and POP\u2010Q stage (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were associated strongly with presence of prolapse symptoms. Uterine descent on ultrasound was associated significantly with POP\u2010Q stage for apical compartment prolapse (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The optimal cut\u2010off value for the definition of abnormal uterine descent on transperineal ultrasound during maximum Valsalva maneuver in the prediction of prolapse symptoms was 4.79\u2009mm above the symphysis pubis (AUC, 0.75 (95%\u2009CI, 0.71\u20130.78)), while the optimal cut\u2010off values in the prediction of prolapse of POP\u2010Q Stage\u2009\u2265\u20091 and POP\u2010Q Stage\u2009\u2265\u20092 were 6.63\u2009mm above the symphysis pubis (AUC, 0.83 (95%\u2009CI, 0.80\u20130.86)) and 8.42\u2009mm below the symphysis pubis (AUC, 0.85 (95%\u2009CI, 0.82\u20130.88)), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The optimal cut\u2010off value to define abnormal uterine descent on transperineal ultrasound during maximum Valsalva maneuver for the prediction of prolapse symptoms in this population of Chinese women was 4.79\u2009mm above the symphysis pubis, close to that for predicting apical compartment prolapse of POP\u2010Q Stage\u2009\u2265\u20091 (6.63\u2009mm above the symphysis pubis). These are somewhat different from values described previously in mainly Caucasian populations. Ethnic differences should be taken into account in the evaluation of pelvic organ prolapse using transperineal ultrasound. \u00a9 2020 International Society of Ultrasound in Obstetrics and Gynecology<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.23524","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T10:24:52Z","timestamp":1603448692000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cut\u2010offs for defining uterine prolapse using transperineal ultrasound in Chinese women:  prospective multicenter study"],"prefix":"10.1002","volume":"58","author":[{"given":"M.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ultrasound The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou, Guangdong Province 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