{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:40:32Z","timestamp":1787776832044,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010552","name":"Departament de Salut, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SLT008\/18\/00156"],"award-info":[{"award-number":["SLT008\/18\/00156"]}],"id":[{"id":"10.13039\/501100010552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/00226"],"award-info":[{"award-number":["PI14\/00226"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PIE15\/00027"],"award-info":[{"award-number":["PIE15\/00027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00861"],"award-info":[{"award-number":["PI16\/00861"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00073"],"award-info":[{"award-number":["PI18\/00073"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report our 10\u2010year experience of protocol\u2010based management of small\u2010for\u2010gestational\u2010age (SGA) fetuses, based on standardized clinical and Doppler criteria, in late\u2010pregnancy cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort was constructed of consecutive singleton pregnancies referred for late\u2010onset (&gt;\u200932\u2009weeks) SGA (defined as estimated fetal weight (EFW) &lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      centile) that were classified as fetal growth restriction  (FGR) or low\u2010risk SGA, based on the severity of smallness (EFW &lt;\u20093\n                      <jats:sup>rd<\/jats:sup>\n                      centile) and the presence of Doppler abnormalities (uterine artery pulsatility index (UtA\u2010PI) \u2265\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile or cerebroplacental ratio (CPR) &lt;\u20095\n                      <jats:sup>th<\/jats:sup>\n                      centile). Low\u2010risk SGA pregnancies were followed at 2\u2010week intervals and delivered electively at 40\u2009weeks. FGR pregnancies were followed at 1\u2010week intervals, or more frequently if there were signs of fetal deterioration, and were delivered electively after 37\u2009+\u20090\u2009weeks' gestation. The occurrence of stillbirth and composite adverse outcome (CAO; defined as neonatal death, metabolic acidosis, need for endotracheal intubation or need for admission to the neonatal intensive care unit) was analyzed in low\u2010risk SGA and FGR pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1197 pregnancies with EFW &lt;\u200910\n                      <jats:sup>th<\/jats:sup>\n                      centile were identified and classified at diagnosis as low\u2010risk SGA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009619; 51.7%) or FGR (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009578; 48.3%). Of these, 160 were delivered before 37\u2009weeks' gestation; for obstetric reasons in 93 (58.1%) cases, severe pre\u2010eclampsia in 33 (20.6%), FGR with severe hypoxia in 47 (29.4%) and stillbirth in four (2.5%)  (indications are non\u2010exclusive). During follow\u2010up, 52\/574 (9.1%) low\u2010risk SGA pregnancies were reclassified as FGR, whereas 22\/463 (4.8%) FGR pregnancies were reclassified as low\u2010risk SGA. Overall, there were no stillbirths in the low\u2010risk SGA group and four in the FGR group, all of which occurred before 37\u2009weeks. There were no instances of neonatal death in pregnancies delivered \u2265\u200937\u2009weeks. The risk of CAO was higher in those meeting antenatal criteria for FGR at 37\u2009weeks than in those classified as low\u2010risk SGA (32\/493 (6.5%)\n                      <jats:italic>vs<\/jats:italic>\n                      15\/544 (2.8%); odds ratio, 2.5 (95%\u00a0CI, 1.3\u20134.6)). In FGR pregnancies, the adjusted odds ratio (95%\u2009CI) for CAO was 6.3 (1.8\u201321.1) in those with EFW &lt;\u20093\n                      <jats:sup>rd<\/jats:sup>\n                      centile, while it was 3.2 (1.5\u20136.8) and 4.2 (1.9\u20138.9) in those with UtA\u2010PI \u2265\u200995\n                      <jats:sup>th<\/jats:sup>\n                      centile and CPR &lt;\u20095\n                      <jats:sup>th<\/jats:sup>\n                      centile, respectively, as compared to FGR pregnancies without each of these criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Protocol\u2010based risk stratification with different management and monitoring schemes for late pregnancy with a suspected SGA baby, based on clinical and Doppler criteria, enables identification and tailored assessment of high\u2010risk FGR, while allowing expectant management with safe perinatal outcome for low\u2010risk SGA fetuses. Copyright \u00a9 2020 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.23537","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:56:49Z","timestamp":1604710609000},"page":"62-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Ten\u2010year experience of protocol\u2010based management of small\u2010for\u2010gestational\u2010age fetuses: perinatal outcome in late\u2010pregnancy cases diagnosed after 32 weeks"],"prefix":"10.1002","volume":"57","author":[{"given":"E.","family":"Meler","sequence":"first","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mazarico","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u (IR\u2010SJD)  Barcelona Spain"},{"name":"Maternal and Child Health Development Network, RETICS Research Institute Carlos III, Spanish Ministry of Economy and Competitiveness  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-9608","authenticated-orcid":false,"given":"E.","family":"Eixarch","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u (IR\u2010SJD)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Peguero","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Boada","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Vellv\u00e9","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Gomez\u2010Roig","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u (IR\u2010SJD)  Barcelona Spain"},{"name":"Maternal and Child Health Development Network, RETICS Research Institute Carlos III, Spanish Ministry of Economy and Competitiveness  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratac\u00f3s","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-1274","authenticated-orcid":false,"given":"F.","family":"Figueras","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal\u2013Fetal and Neonatal Medicine Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u, IDIBAPS, University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14714"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70494-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7087"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17544"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.12.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12371"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5315"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04050381.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.02.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000289"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.06.039"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10150"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00131-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19117"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21940"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20272"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18824"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.16287"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5386"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.02.009"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4412"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.23537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:20:39Z","timestamp":1782746439000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.23537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/uog.23537"],"URL":"https:\/\/doi.org\/10.1002\/uog.23537","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}