{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:06:01Z","timestamp":1785549961460,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effectiveness and safety of Foley catheter and oral misoprostol for induction of labor (IOL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Cochrane Review on Mechanical Methods for Induction of Labour and Ovid MEDLINE, EMBASE via Ovid, Ovid Emcare, CINAHL Plus, \n<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> and Scopus, from inception to April 2019, were searched for randomized controlled trials (RCTs) comparing Foley catheter to oral misoprostol for IOL in viable singleton gestations. Eligible trials for which raw data were obtained were included and individual participant data meta\u2010analysis was performed. Primary outcomes were vaginal birth, a composite of adverse perinatal outcome (including stillbirth, neonatal death, neonatal seizures, admission to the neonatal intensive care unit, severe respiratory compromise or meconium aspiration syndrome) and a composite of adverse maternal outcome (including admission to the intensive care unit, maternal infection, severe postpartum hemorrhage, maternal death or uterine rupture). The quality of the included RCTs was assessed using the Cochrane Risk of Bias 2 tool and the certainty of evidence was evaluated using the GRADE approach. A two\u2010stage random\u2010effects model was used for meta\u2010analysis according to the intention\u2010to\u2010treat principle and interactions between treatment and baseline characteristics were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of seven eligible trials, four provided individual participant data for a total of 2815 participants undergoing IOL, of whom 1399 were assigned to Foley catheter and 1416 to oral misoprostol. All four trials provided data for each of the primary outcomes in all 2815 women. Compared with those receiving oral misoprostol, Foley catheter recipients had a slightly decreased chance of vaginal birth (risk ratio (RR), 0.95 (95%\u2009CI, 0.91\u20130.99); <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>, 2.0%; moderate\u2010certainty evidence). A trend towards a lower rate of composite adverse perinatal outcome was found in women undergoing IOL using a Foley catheter compared with oral misoprostol (RR, 0.71 (95%\u2009CI, 0.48\u20131.05); <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>, 14.9%; low\u2010certainty evidence). Composite adverse maternal outcome did not differ between the groups (RR, 1.00 (95%\u2009CI, 0.97\u20131.03); <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>, 0%; moderate\u2010certainty evidence). Meta\u2010analyses of effect modifications did not show significant interactions between intervention and parity or gestational age for any of the primary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For women undergoing IOL, Foley catheter is less effective than oral misoprostol, as it was associated with fewer vaginal births. However, while we found no significant difference in maternal safety, Foley catheter induction may reduce adverse perinatal outcomes. Copyright \u00a9 2020 ISUOG. Published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.23563","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T15:17:13Z","timestamp":1606835833000},"page":"215-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Foley catheter <i>vs<\/i> oral misoprostol for induction of labor: individual participant data meta\u2010analysis"],"prefix":"10.1002","volume":"57","author":[{"given":"J. I.","family":"Kemper","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-0909","authenticated-orcid":false,"given":"W.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Goni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Women's &amp; Children's Health University of Liverpool, Liverpool Women's Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Alfirevic","sequence":"additional","affiliation":[{"name":"Department of Women's &amp; Children's Health University of Liverpool, Liverpool Women's Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bracken","sequence":"additional","affiliation":[{"name":"Gynuity Health Projects  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mundle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology All India Institute of Medical Sciences  Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Goonewardene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of Ruhuna  Galle Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ten Eikelder","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Wilhelmina Children's Hospital Birth Centre University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. O.","family":"Rengerink","sequence":"additional","affiliation":[{"name":"Julius Center for Health Science and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kruit","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-550X","authenticated-orcid":false,"given":"B. W.","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Australia"},{"name":"Monash Women's Monash Health  Melbourne Australia"},{"name":"Aberdeen Centre for Women's Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Australia"},{"name":"Monash Women's Monash Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Australian Institute of Health and Welfare. Australia's mothers and babies 2015 \u2010 in brief.https:\/\/www.aihw.gov.au\/getmedia\/728e7dc2\u2010ced6\u201047b7\u2010addd\u2010befc9d95af2d\/aihw\u2010per\u201091\u2010inbrief.pdf.aspx?inline=true."},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Births: Final Data for 2017","volume":"67","author":"Martin JA","year":"2018","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065612"},{"key":"e_1_2_6_5_1","article-title":"Mechanical methods for induction of labour","volume":"10","author":"de Vaan MD","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1675351"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13456"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70090-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4038\/sljog.v36i3.7714"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1580608"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31367-3"},{"key":"e_1_2_6_12_1","first-page":"75","article-title":"Comparative evaluation of oral misoprostol, vaginal misoprostol and intracervical Foley's catheter for induction of labour at term","volume":"11","author":"Sheikher C","year":"2009","journal-title":"JK Sci"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v62i2.8470"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00084-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000361"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c221"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.3656"},{"key":"e_1_2_6_18_1","unstructured":"Covidence systematic review software. 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