{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T01:34:56Z","timestamp":1774402496107,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the diagnostic performance of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) in the prediction of deep myometrial invasion (DMI) and cervical stromal invasion (CSI) in patients with low\u2010grade (Grade 1 or 2) endometrioid endometrial cancer (EEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study including all patients with low\u2010grade EEC diagnosed between October 2013 and July 2018 at the Vall d'Hebron Hospital in Barcelona, Spain. Preoperative staging was performed using TVS and MRI, followed by surgical staging. Final histology was considered as the reference standard. Sensitivity, specificity, likelihood ratios and diagnostic accuracy were calculated for both imaging techniques in the prediction of DMI and CSI, and the agreement index was calculated for both techniques. The STARD 2015 guidelines were followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 131 patients with low\u2010grade EEC were included consecutively. Sensitivity was higher for TVS than for MRI both for the prediction of DMI (69% (95%\u2009CI, 53\u201382%) <jats:italic>vs<\/jats:italic> 51% (95%\u2009CI, 36\u201366%), respectively) and CSI (43% (95%\u2009CI, 27\u201361%) <jats:italic>vs<\/jats:italic> 24% (95%\u2009CI, 12\u201341%), respectively). Specificity was similar for TVS and MRI in the prediction of DMI (87% (95%\u2009CI, 78\u201393%) <jats:italic>vs<\/jats:italic> 91% (95%\u2009CI, 82\u201396%)) and equal in the prediction of CSI (97% (95%\u2009CI, 91\u201399%) for both). The agreement index between TVS and MRI was 0.84 (95%\u2009CI, 0.76\u20130.90) for DMI and 0.92 (95%\u2009CI, 0.85\u20130.96) for CSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The diagnostic performance of TVS is similar to that of MRI for the prediction of DMI and CSI in low\u2010grade EEC, and TVS can play a role as a first\u2010line imaging technique in the preoperative evaluation of low\u2010grade EEC. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.23607","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:57:04Z","timestamp":1612573024000},"page":"469-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Diagnostic performance of transvaginal ultrasound and magnetic resonance imaging for preoperative evaluation of low\u2010grade endometrioid endometrial carcinoma: prospective comparative study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-1440","authenticated-orcid":false,"given":"M.","family":"Cubo\u2010Abert","sequence":"first","affiliation":[{"name":"Gynecology Service, Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Biomedical Research Group in Gynecology, Vall d'Hebron Research Institute (VHIR)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"D\u00edaz\u2010Feijoo","sequence":"additional","affiliation":[{"name":"Gynecology Service, Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Gynecology Service, Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Biomedical Research Group in Gynecology, Vall d'Hebron Research Institute (VHIR)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.\u2010L.","family":"Rodr\u00edguez\u2010M\u00edas","sequence":"additional","affiliation":[{"name":"Gynecology Service, Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vera","sequence":"additional","affiliation":[{"name":"Radiology Department, Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"P\u00e9rez\u2010Hoyos","sequence":"additional","affiliation":[{"name":"Statistics and Bioinformatics Unit, Vall d'Hebron Research Institute (VHIR)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010J.","family":"G\u00f3mez\u2010Cabeza","sequence":"additional","affiliation":[{"name":"Gynecology Service, Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gil\u2010Moreno","sequence":"additional","affiliation":[{"name":"Gynecology Service, Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Biomedical Research Group in Gynecology, Vall d'Hebron Research Institute (VHIR)  Barcelona Spain"},{"name":"CIBERONC  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.11.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.02.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67063-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2017.28.e86"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14682"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2019.04.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1992.02010040.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.160.3.8430547"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.161.3.8352114"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199509000-00013"},{"key":"e_1_2_8_14_1","first-page":"193","article-title":"Prediction of myometrial invasion in patients with endometrial carcinoma: comparison of magnetic resonance imaging, transvaginal ultrasonography, and gross visual inspection","volume":"28","author":"Yahata T","year":"2007","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5295"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181ad3eb6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.11.025"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2019.101647"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13248"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/105294199277860"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5527"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7487"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90260-R"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2503080877"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12499"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7309"},{"key":"e_1_2_8_27_1","unstructured":"Alan Schwartz calculatorversion 2010042101 available from http:\/\/araw.mede.uic.edu\/cgi\u2010bin\/testcalc.pl."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2015.26.3.201"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14905"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2019.09.018"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5515-y"},{"key":"e_1_2_8_32_1","first-page":"128","article-title":"The value of transvaginal sonography in the preoperative assessment of myometrial invasion in high and low grade endometrial cancer and in comparison to frozen section in grade 1 disease","volume":"21","author":"Fishman A","year":"2000","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20374"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2018-000045"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000194"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2400-y"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.23607","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T19:32:58Z","timestamp":1747942378000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.23607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/uog.23607"],"URL":"https:\/\/doi.org\/10.1002\/uog.23607","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2020-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}