{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:08:05Z","timestamp":1782731285875,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe and compare ultrasound and Doppler findings in pregnant women who were positive for severe acute respiratory syndrome coronavirus\u00a02 (SARS\u2010CoV\u20102) with findings in those who were SARS\u2010CoV\u20102\u2010negative, evaluated during the pandemic period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective case\u2013control study, we analyzed data from 106 pregnant women who tested positive for SARS\u2010CoV\u20102 at the time of, or within 1\u2009week of, an ultrasound scan between 1 May and 31 August 2020. Scans were either performed for routine fetal evaluation or indicated due to a positive SARS\u2010CoV\u20102 test. Forty\u2010nine women were symptomatic and 57 were asymptomatic. For comparison, we analyzed data from 103 pregnant women matched for maternal age, parity, body mass index and gestational age at the time of the ultrasound scan. These control women did not report symptoms of SARS\u2010CoV\u20102 infection at the time of the ultrasound scan or at the time of admission for delivery and had a negative SARS\u2010CoV\u20102 test at admission for delivery. Fetal biometry, fetal anatomy, amniotic fluid volume and Doppler parameters, including umbilical and fetal middle cerebral artery pulsatility indices, cerebroplacental ratio and biophysical profile (BPP), were evaluated as indicated. Biometric and Doppler values were converted to <jats:italic>Z<\/jats:italic>\u2010scores for comparison. Our primary outcome, an adverse prenatal composite outcome (APCO) included any one or more of: small\u2010for\u2010gestational\u2010age (SGA) fetus, oligohydramnios, abnormal BPP, abnormal Doppler velocimetry and fetal death. Comorbidities, delivery information and neonatal outcome were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010seven (82.1%) women who were positive for SARS\u2010CoV\u20102 had a body mass index &gt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup>. SARS\u2010CoV\u20102\u2010positive women had a higher prevalence of diabetes (26\/106 (24.5%) <jats:italic>vs<\/jats:italic> 13\/103 (12.6%); <jats:italic>P<\/jats:italic>\u2009=\u20090.03), but not of pre\u2010eclampsia (21\/106 (19.8%) <jats:italic>vs<\/jats:italic> 11\/103 (10.7%); <jats:italic>P<\/jats:italic>\u2009=\u20090.08), compared with controls. The prevalence of APCO was not significantly different between SARS\u2010CoV\u20102\u2010positive women (19\/106 (17.9%)) and controls (9\/103 (8.7%)) (<jats:italic>P<\/jats:italic>\u2009=\u20090.06). There were no differences between SARS\u2010CoV\u20102\u2010positive women and controls in the prevalence of SGA fetuses (12\/106 (11.3%) <jats:italic>vs<\/jats:italic> 6\/103 (5.8%); <jats:italic>P<\/jats:italic>\u2009=\u20090.17), fetuses with abnormal Doppler evaluation (8\/106 (7.5%) <jats:italic>vs<\/jats:italic> 2\/103 (1.9%); <jats:italic>P<\/jats:italic>\u2009=\u20090.08) and fetuses with abnormal BPP (4\/106 (3.8%) <jats:italic>vs<\/jats:italic> 0\/103 (0%); <jats:italic>P<\/jats:italic>\u2009=\u20090.14). There were two fetal deaths in women who were positive for SARS\u2010CoV\u20102 and these women had a higher rate of preterm delivery \u2264\u200935\u2009weeks of gestation (22\/106 (20.8%) <jats:italic>vs<\/jats:italic> 9\/103 (8.7%); odds ratio, 2.73 (95%\u2009CI, 1.19\u20136.3); <jats:italic>P<\/jats:italic>\u2009=\u20090.01) compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no significant differences in abnormal fetal ultrasound and Doppler findings observed between pregnant women who were positive for SARS\u2010CoV\u20102 and controls. However, preterm delivery \u2264\u200935\u2009weeks was more frequent among SARS\u2010CoV\u20102\u2010positive women. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.23642","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T20:44:15Z","timestamp":1617309855000},"page":"111-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Ultrasound and Doppler findings in pregnant women with\u00a0<scp>SARS\u2010CoV<\/scp>\u20102 infection"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-9245","authenticated-orcid":false,"given":"E.","family":"Soto\u2010Torres","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-3984","authenticated-orcid":false,"given":"E.","family":"Hernandez\u2010Andrade","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Huntley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mendez\u2010Figueroa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences, McGovern Medical School University of Texas, Health Science Center at Houston (UTHealth)  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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