{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:20:45Z","timestamp":1792293645599,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the performance of transvaginal and transabdominal ultrasound with that of the first\u2010line staging method (contrast\u2010enhanced computed tomography (CT)) and a novel technique, whole\u2010body magnetic resonance imaging with diffusion\u2010weighted sequence (WB\u2010DWI\/MRI), in the assessment of peritoneal involvement (carcinomatosis), lymph\u2010node staging and prediction of non\u2010resectability in patients with suspected ovarian cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between March 2016 and October 2017, all consecutive patients with suspicion of ovarian cancer and surgery planned at a gynecological oncology center underwent preoperative staging and prediction of non\u2010resectability with ultrasound, CT and WB\u2010DWI\/MRI. The evaluation followed a single, predefined protocol, assessing peritoneal spread at 19 sites and lymph\u2010node metastasis at eight sites. The prediction of non\u2010resectability was based on abdominal markers. Findings were compared to the reference standard (surgical findings and outcome and histopathological evaluation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010seven patients with confirmed ovarian cancer were analyzed. Among them, 51 (76%) had advanced\u2010stage and 16 (24%) had early\u2010stage ovarian cancer. Diagnostic laparoscopy only was performed in 16% (11\/67) of the cases and laparotomy in 84% (56\/67), with no residual disease at the end of surgery in 68% (38\/56), residual disease \u2264\u20091\u2009cm in 16% (9\/56) and residual disease &gt;\u20091\u2009cm in 16% (9\/56). Ultrasound and WB\u2010DWI\/MRI performed better than did CT in the assessment of overall peritoneal carcinomatosis (area under the receiver\u2010operating\u2010characteristics curve (AUC), 0.87, 0.86 and 0.77, respectively). Ultrasound was not inferior to CT (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). For assessment of retroperitoneal lymph\u2010node staging (AUC, 0.72\u20130.76) and prediction of non\u2010resectability in the abdomen (AUC, 0.74\u20130.80), all three methods performed similarly. In general, ultrasound had higher or identical specificity to WB\u2010DWI\/MRI and CT at each of the 19 peritoneal sites evaluated, but lower or equal sensitivity in the abdomen. Compared with WB\u2010DWI\/MRI and CT, transvaginal ultrasound had higher accuracy (94%\n                      <jats:italic>vs<\/jats:italic>\n                      91% and 85%, respectively) and sensitivity (94%\n                      <jats:italic>vs<\/jats:italic>\n                      91% and 89%, respectively) in the detection of carcinomatosis in the pelvis. Better accuracy and sensitivity of ultrasound (93% and 100%) than WB\u2010DWI\/MRI (83% and 75%) and CT (84% and 88%) in the evaluation of deep rectosigmoid wall infiltration, in particular, supports the potential role of ultrasound in planning rectosigmoid resection. In contrast, for the bowel serosal and mesenterial assessment, abdominal ultrasound had the lowest accuracy (70%, 78% and 79%, respectively) and sensitivity (42%, 65% and 65%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first prospective study to document that, in experienced hands, ultrasound may be an alternative to WB\u2010DWI\/MRI and CT in ovarian cancer staging, including peritoneal and lymph\u2010node evaluation and prediction of non\u2010resectability based on abdominal markers of non\u2010resectability. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.23654","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T12:16:12Z","timestamp":1618834572000},"page":"248-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Preoperative staging of ovarian cancer: comparison between ultrasound,\n                    <scp>CT<\/scp>\n                    and whole\u2010body diffusion\u2010weighted\n                    <scp>MRI<\/scp>\n                    (\n                    <scp>ISAAC<\/scp>\n                    study)"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-3218","authenticated-orcid":false,"given":"D.","family":"Fischerova","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-8529","authenticated-orcid":false,"given":"P.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maternidade Alfredo da Costa, Centro Hospitalar Lisboa Central  Lisbon Portugal"},{"name":"First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-2338","authenticated-orcid":false,"given":"A.","family":"Burgetova","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Masek","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-1204","authenticated-orcid":false,"given":"J.","family":"Slama","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-4158","authenticated-orcid":false,"given":"R.","family":"Kocian","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-1890","authenticated-orcid":false,"given":"F.","family":"Fr\u00fchauf","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5266-8895","authenticated-orcid":false,"given":"M.","family":"Zikan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bulovka Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-4378","authenticated-orcid":false,"given":"L.","family":"Dusek","sequence":"additional","affiliation":[{"name":"Institute of Health Information and Statistics of the Czech Republic  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-6124","authenticated-orcid":false,"given":"P.","family":"Dundr","sequence":"additional","affiliation":[{"name":"Department of Pathology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-9356","authenticated-orcid":false,"given":"D.","family":"Cibula","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"113","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs","author":"Lee KR","year":"2003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000767"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001248"},{"key":"e_1_2_8_6_1","first-page":"672","article-title":"ESMO\u2013ESGO Ovarian Cancer Consensus Conference Working Group. ESMO\u2010ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease","volume":"30","author":"Colombo N","year":"2019","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2018-000066"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-3083-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151516"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01015.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8803"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14892"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8633-6_22"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10068"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.10.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001041"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15942"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10054"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20501"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.02.016"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.233025712"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10100"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2013.0056"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.336125060"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23617"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015040"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930440207"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.09.013"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2358"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17646"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.06.010"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.215.3.r00jn25761"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.23654","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.23654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:40:28Z","timestamp":1748338828000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.23654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/uog.23654"],"URL":"https:\/\/doi.org\/10.1002\/uog.23654","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"2020-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}