{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:11:23Z","timestamp":1792653083207,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate interobserver agreement for the assessment of local tumor extension in women with cervical cancer, among experienced and less experienced observers, using transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The TVS observers were all gynecologists and consultant ultrasound specialists, six with and seven without previous experience in cervical cancer imaging. The MRI observers were five radiologists experienced in pelvic MRI and four less experienced radiology residents without previous experience in MRI of the pelvis. The less experienced TVS observers and all MRI observers underwent a short basic training session in the assessment of cervical tumor extension, while the experienced TVS observers received only a written directive. All observers were assigned the same images from cervical cancer patients at all stages (<jats:italic>n<\/jats:italic>\u2009=\u200960) and performed offline evaluation to answer the following three questions: (1) Is there a visible primary tumor? (2) Does the tumor infiltrate &gt;\u2009\u2153 of the cervical stroma? and (3) Is there parametrial invasion? Interobserver agreement within the four groups of observers was assessed using Fleiss kappa (\u03ba) with 95%\u2009CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Experienced and less experienced TVS observers, respectively, had moderate interobserver agreement with respect to tumor detection (\u03ba (95%\u2009CI), 0.46 (0.40\u20130.53) and 0.46 (0.41\u20130.52)), stromal invasion &gt;\u2009\u2153 (\u03ba\u00a0(95%\u2009CI), 0.45 (0.38\u20130.51) and 0.53 (0.40\u20130.58)) and parametrial invasion (\u03ba (95%\u2009CI), 0.57 (0.51\u20130.64) and 0.44 (0.39\u20130.50)). Experienced MRI observers had good interobserver agreement with respect to tumor detection (\u03ba (95%\u2009CI), 0.70 (0.62\u20130.78)), while less experienced MRI observers had moderate agreement (\u03ba (95%\u2009CI), 0.51 (0.41\u20130.62)), and both experienced and less experienced MRI observers, respectively, had good interobserver  agreement regarding stromal invasion (\u03ba (95%\u2009CI), 0.80 (0.72\u20130.88) and 0.71 (0.61\u20130.81)) and parametrial invasion (\u03ba (95%\u2009CI), 0.69 (0.61\u20130.77) and 0.71 (0.61\u20130.81)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found interobserver agreement for the assessment of local tumor extension in patients with cervical cancer to be moderate for TVS and moderate\u2010to\u2010good for MRI. The level of interobserver agreement was associated with experience among TVS observers only  for parametrial invasion. \u00a9 2021 The Authors. Ultrasound in Obstetrics &amp; Gynecology published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.23662","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T19:39:28Z","timestamp":1619725168000},"page":"773-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interobserver agreement of transvaginal ultrasound and\u00a0magnetic resonance imaging in local staging of\u00a0cervical cancer"],"prefix":"10.1002","volume":"58","author":[{"given":"K.","family":"P\u00e1lsd\u00f3ttir","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Division of Pelvic Cancer, Theme Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-6984","authenticated-orcid":false,"given":"S.","family":"Fridsten","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Diagnostic Radiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Blomqvist","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Diagnostic Radiology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Alagic","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Intervention and Technology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-3218","authenticated-orcid":false,"given":"D.","family":"Fischerova","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gaurilcikas","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hasselrot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Danderyd Hospital  Stockholm Sweden"},{"name":"Department of Clinical Sciences, Danderyd Hospital Division of Obstetrics and Gynecology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"J\u00e4derling","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Diagnostic Radiology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Radiology Capio S:t G\u00f6ran Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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