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Fetuses with CHD were stratified into two categories according to the main expected pattern of cerebral arterial oxygen supply: Class A, moderately to severely reduced oxygen supply (left outflow tract obstruction and transposition of the great arteries) and Class B, near normal or mildly impaired oxygenated blood supply to the brain (other CHD). Transvaginal NSG was performed at 32\u201336\u2009weeks in all fetuses to evaluate CC length, CC total area and areas of CC subdivisions in the midsagittal plane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CHD fetuses had a significantly smaller CC area as compared to controls (7.91\u2009\u00b1\u20091.30 <jats:italic>vs<\/jats:italic> 9.01\u2009\u00b1\u20091.44\u2009mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), which was more pronounced in the most posterior part of the CC. There was a significant linear trend for reduced CC total area across the three clinical groups, with CHD Class\u2010A cases showing more prominent changes (controls, 9.01\u2009\u00b1\u20091.44 <jats:italic>vs<\/jats:italic> CHD Class B, 8.18\u2009\u00b1\u20091.21 <jats:italic>vs<\/jats:italic> CHD Class A, 7.53\u2009\u00b1\u20091.33\u2009mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetuses with major CHD had a smaller CC compared with controls, and the difference was more marked in the CHD subgroup with expected poorer brain oxygenation. Sonographic CC size could be a clinically feasible marker of abnormal white matter development in CHD. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.23684","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T06:50:10Z","timestamp":1621234210000},"page":"220-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Corpus callosum size by neurosonography in fetuses with congenital heart defect and relationship with expected pattern of brain oxygen supply"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-0050","authenticated-orcid":false,"given":"M.","family":"P\u00e9rez\u2010Cruz","sequence":"first","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u Esplugues de Llobregat  Barcelona Spain"},{"name":"Maternal and Child Health and Development Network II (SAMID II) funded by Instituto de Salud Carlos III (ISCIII), Sub\u2010Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gibert","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Masoller","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Marimon","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lip\u2010Sosa","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bennasar","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bonet\u2010Carne","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Universitat Polit\u00e8cnica de Catalunya BarcelonaTech  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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