{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:28:22Z","timestamp":1778862502806,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the possibility of carrying out routine screening for pre\u2010eclampsia (PE) with delivery at &lt;\u200928, &lt;\u200932, &lt;\u200936\u2009weeks' gestation by maternal factors, uterine artery pulsatility index (UtA\u2010PI) and mean arterial pressure (MAP) in all pregnancies and reserving measurements of placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) for only a subgroup of the population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study in two UK maternity hospitals involving women with singleton pregnancy attending for routine assessment at 19\u201324\u2009weeks' gestation. The improvement in performance of screening for PE, at fixed risk cut\u2010offs, by the addition of serum PlGF and sFlt\u20101 to screening by maternal factors, UtA\u2010PI and MAP, was estimated. We examined a policy of contingent screening in which biochemical testing was reserved for only a subgroup of the population. The main outcome measures were the additional contribution of PlGF and sFlt\u20101 to the performance of screening for PE and the proportion of the population requiring measurement of PlGF and sFlt\u20101 for maximum performance of screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 37\u2009886 singleton pregnancies. At each risk cut\u2010off, the highest detection rates for delivery with PE and the lowest screen\u2010positive rates were achieved in screening with maternal factors, UtA\u2010PI, MAP, PlGF and sFlt\u20101. The maximum performance by such screening was also achieved by contingent screening in which PlGF and sFlt\u20101 were measured in only about 40% of the population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The performance of screening for PE by a combination of maternal factors, UtA\u2010PI and MAP is improved by measurement of PlGF and sFlt\u20101 in about 40% of the population. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.23742","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T14:31:19Z","timestamp":1627309879000},"page":"553-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Contingent screening in stratification of pregnancy care based on risk of pre\u2010eclampsia at 19\u201324\u2009weeks' gestation"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2160-2548","authenticated-orcid":false,"given":"M.","family":"Litwinska","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Litwinska","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bouariu","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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