{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:38Z","timestamp":1786978598072,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["Foundation under grant agreement LCF\/PR\/GN18\/10310"],"award-info":[{"award-number":["Foundation under grant agreement LCF\/PR\/GN18\/10310"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00861 PI18\/00073 integrados en el Plan Naci"],"award-info":[{"award-number":["PI16\/00861 PI18\/00073 integrados en el Plan Naci"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010648","name":"Universitaire Ziekenhuizen Leuven, KU Leuven","doi-asserted-by":"publisher","award":["KOOR fonds"],"award-info":[{"award-number":["KOOR fonds"]}],"id":[{"id":"10.13039\/501100010648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence of brain anomalies at the time of preoperative magnetic resonance imaging (MRI) assessment in fetuses eligible for prenatal open spina bifida (OSB) repair, and to explore the relationship between brain abnormalities and features of the spinal defect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cross\u2010sectional study, conducted in three fetal medicine centers, of fetuses eligible for OSB fetal surgery repair between January 2009 and December 2019. MRI images obtained as part of the presurgical assessment were re\u2010evaluated by two independent observers, blinded to perinatal results, to assess: (1) the type and area of the defect and its anatomical level; (2) the presence of any structural central nervous system (CNS) anomaly and abnormal ventricular wall; and (3) fetal head and brain biometry. Binary regression analyses were performed and data were adjusted for type of defect, upper level of the lesion (ULL), gestational age (GA) at MRI and fetal medicine center. Multiple logistic regression analysis was performed in order to identify lesion characteristics and brain anomalies associated with a higher risk of presence of abnormal corpus callosum (CC) and\/or heterotopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 115 fetuses included, 91 had myelomeningocele and 24 had myeloschisis. Anatomical level of the lesion was thoracic in seven fetuses, L1\u2013L2 in 13, L3\u2013L5 in 68 and sacral in 27. Median GA at MRI was 24.7 (interquartile range, 23.0\u201325.7) weeks. Overall, 52.7% of cases had at least one additional brain anomaly. Specifically, abnormal CC was observed in 50.4% of cases and abnormality of the ventricular wall in 19.1%, of which 4.3% had nodular heterotopia. Factors associated independently with higher risk of abnormal CC and\/or heterotopia were non\u2010sacral ULL (odds ratio (OR), 0.51 (95%\u2009CI, 0.26\u20130.97);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.043), larger ventricular width (per mm) (OR, 1.23 (95%\u2009CI, 1.07\u20131.43);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) and presence of abnormal cavum septi pellucidi (OR, 3.76 (95%\u2009CI, 1.13\u201312.48);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Half of the fetuses assessed for OSB repair had an abnormal CC and\/or an abnormal ventricular wall prior to prenatal repair. The likelihood of brain abnormalities was increased in cases with a non\u2010sacral lesion and wider lateral ventricles. These findings highlight the importance of a detailed preoperative CNS evaluation of fetuses with OSB. \u00a9 2021 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.23761","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T02:24:19Z","timestamp":1629080659000},"page":"804-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence of supratentorial anomalies assessed by magnetic resonance imaging in fetuses with open spina bifida"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8643-1578","authenticated-orcid":false,"given":"L.","family":"Trigo","sequence":"first","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"My FetUZ Fetal Research Center, Department of Development and Regeneration, Biomedical Sciences, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-9608","authenticated-orcid":false,"given":"E.","family":"Eixarch","sequence":"additional","affiliation":[{"name":"BCNatal\u2013Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u University of Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bottura","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Therapy Group, Hospital Sabar\u00e1  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dalaqua","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Israelita Albert Einsten  S\u00e3o Paulo Brazil"},{"name":"School of Medicine, Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein (FICSAE)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Therapy Group, Hospital Sabar\u00e1  S\u00e3o Paulo Brazil"},{"name":"School of Medicine, Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein (FICSAE)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"De Catte","sequence":"additional","affiliation":[{"name":"Department of Radiology UZ KU Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynecology UZ KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Demaerel","sequence":"additional","affiliation":[{"name":"Department of Radiology UZ KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dymarkowski","sequence":"additional","affiliation":[{"name":"Department of Radiology UZ KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"J.","family":"Deprest","sequence":"additional","affiliation":[{"name":"My FetUZ Fetal Research Center, Department of Development and Regeneration, Biomedical Sciences, KU Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynecology UZ KU Leuven  Leuven Belgium"},{"name":"Institute of Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-9187","authenticated-orcid":false,"given":"D. 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