{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T14:22:18Z","timestamp":1788099738838,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the pregnancy and obstetric outcomes of patients with congenital uterus didelphys who achieved clinical pregnancy after\n                      <jats:italic>in\u2010vitro<\/jats:italic>\n                      fertilization (IVF)\/intracytoplasmic sperm injection (ICSI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective matched\u2010cohort study of 83 infertile patients with uterus didelphys who underwent IVF\/ICSI and achieved clinical pregnancy from January 2005 to December 2018 at our center. For each patient in the study group, three control patients with normal uterine morphology who underwent IVF\/ICSI in 2018 were selected randomly. Patients in the two groups were matched for number of gestational sacs, maternal age, infertility type, cause of infertility, fertilization method, endometrial thickness 1\u2009day before embryo transfer and number of embryos transferred. The classification of congenital uterine anomalies was based on the American Fertility Society system (1988). The pregnancy and obstetric outcomes of the didelphic and control groups were compared separately for singleton and twin pregnancies, and for all pregnancies combined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In singleton pregnancies, women with uterus didelphys had increased risk of preterm birth (odds ratio (OR), 4.68; rate difference (RD), 0.14;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), Cesarean section (OR, 2.80; RD, 0.17;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.016) and birth weight &lt;\u20092500\u2009g (OR, 4.06; RD, 0.10;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017) compared to women with normal uterine morphology. In twin pregnancies, the presence of uterus didelphys was associated with increased risk of preterm delivery (OR, 4.79; RD, 0.37;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006), perinatal mortality (OR, 3.16; RD, 0.19;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.043) and birth weight &lt;\u20092500\u2009g (OR, 9.57; RD, 0.35;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presence of uterus didelphys was associated with significantly increased risk of some adverse pregnancy outcomes compared to pregnancies with normal uterine morphology in women who underwent IVF\/ICSI. A twin pregnancy in women with uterus didelphys was associated with worse perinatal outcome. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.24750","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T03:27:21Z","timestamp":1629689241000},"page":"543-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pregnancy outcome after\n                    <i>in\u2010vitro<\/i>\n                    fertilization\/intracytoplasmic sperm injection in women with congenital uterus didelphys"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-8776","authenticated-orcid":false,"given":"P.","family":"Cai","sequence":"first","affiliation":[{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha City China"},{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha City China"},{"name":"Clinical Research Centre for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha City China"},{"name":"Clinical Research Centre for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lin","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha City China"},{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha City China"},{"name":"Clinical Research Centre for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Peng","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Public Health Central South University  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0986-760X","authenticated-orcid":false,"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha City China"},{"name":"Clinical Research Centre for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7474-0680","authenticated-orcid":false,"given":"F.","family":"Gong","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha City China"},{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha City China"},{"name":"Clinical Research Centre for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.03.043"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0382-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.09.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.847082"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10056"},{"issue":"558","key":"e_1_2_8_8_1","first-page":"e1","article-title":"Congenital uterine anomalies and adverse pregnancy outcomes","volume":"205","author":"Hua M","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_9_1","first-page":"418","article-title":"Obstetric outcome of women with uterine anomalies in China","volume":"123","author":"Zhang Y","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1438403"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.09.069"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(84)90113-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00259-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5811\/cpcem.2016.11.33052"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crwh.2019.e00118"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56040198"},{"key":"e_1_2_8_17_1","first-page":"353","article-title":"Gestational aspects of uterus didelphys","volume":"33","author":"Fedele L","year":"1988","journal-title":"J Reprod Med"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55141-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137860"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.10.2277"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348209156548"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.923"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8968"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)59942-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01599-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg030"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.07.015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.09.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136618"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.5.1325"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00518-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-2815-4"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.12.012"},{"issue":"580","key":"e_1_2_8_35_1","first-page":"e1","article-title":"Outcomes in twin pregnancies reduced to singleton pregnancies compared with ongoing twin pregnancies","volume":"213","author":"Gupta S","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_36_1","first-page":"159","article-title":"Retrospective analysis of outcomes of selectively or spontaneously reduced multiple pregnancies out of 6917 in vitro fertilization\u2010embryo transfer pregnancy cycles","volume":"52","author":"Chen QL","year":"2017","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6945"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.24750","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T06:36:13Z","timestamp":1692858973000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.24750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/uog.24750"],"URL":"https:\/\/doi.org\/10.1002\/uog.24750","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"2020-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}