{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:19:12Z","timestamp":1790680752531,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fetal intracranial hemorrhage (ICH) is associated with an increased risk of perinatal mortality and morbidity. Healthcare professionals often find it challenging to counsel parents due to its rarity and diverse presentation. The aim of this systematic review and meta\u2010analysis was to investigate the perinatal outcome of fetuses with ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE, \n<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> and The Cochrane Library databases were searched. Inclusion criteria were studies reporting the outcome of fetuses, newborns and infants diagnosed with ICH. The primary outcome was perinatal death (PND), defined as the sum of intrauterine (IUD) and neonatal death (NND). The secondary outcomes were stillbirth, NND, IUD, termination of pregnancy, need for surgery\/shunting at birth, cerebral palsy (defined according to the European Cerebral Palsy Network and classified as diplegia, hemiplegia, quadriplegia, dyskinetic or mixed), neurodevelopmental delay and intact survival. All outcomes were explored in the included fetuses with ICH. A subgroup analysis according to the location of the hemorrhage (intra\u2010axial and extra\u2010axial) was also planned. Meta\u2010analysis of proportions was used to combine data, and pooled proportions and their 95%\u2009CI were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen studies (193 fetuses) were included in the meta\u2010analysis. PND occurred in 14.6% (95%\u2009CI, 7.3\u201324.0%) of fetuses with ICH. Among liveborn cases, 27.6% (95%\u2009CI, 12.5\u201345.9%) required shunt placement or surgery after birth and 32.0% (95%\u2009CI, 22.2\u201342.6%) had cerebral palsy. Furthermore, 16.7% (95%\u2009CI, 8.4\u201327.2%) of cases had mild neurodevelopmental delay, while 31.1% (95%\u2009CI, 19.0\u201344.7%) experienced severe adverse neurodevelopmental outcome. Normal neurodevelopmental outcome was reported in 53.6% of fetuses. Subgroup analysis according to the location of ICH showed that PND occurred in 13.3% (95%\u2009CI, 5.7\u201323.4%) of fetuses with intra\u2010axial bleeding and 26.7% (95%\u2009CI, 5.3\u201356.8%) of those with extra\u2010axial bleeding. In fetuses with intra\u2010axial hemorrhage, 25.2% (95%\u2009CI, 11.0\u201342.9%) required shunt placement or surgery after birth and 25.5% (95%\u2009CI, 15.3\u201337.2%) experienced cerebral palsy. In fetuses with intra\u2010axial hemorrhage, mild and severe neurodevelopmental delay was observed in 14.9% (95%\u2009CI, 12.0\u201327.0%) and 32.8% (95%\u2009CI, 19.8\u201347.4%) of cases, respectively, while 53.2% (95%\u2009CI, 37.0\u201369.1%) experienced normal neurodevelopmental outcome. The incidence of mortality and postnatal neurodevelopmental outcome in fetuses with extra\u2010axial hemorrhage could not be estimated reliably due to the small number of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetuses with a prenatal diagnosis of ICH are at high risk of perinatal mortality and adverse neurodevelopmental outcome. Postnatal shunt placement or surgery was required in 28% of cases and cerebral palsy was diagnosed in approximately one\u2010third of infants. Due to the rarity of ICH, multicenter prospective registries are warranted to collect high\u2010quality data. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24766","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T14:28:41Z","timestamp":1631802521000},"page":"585-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Perinatal and long\u2010term outcome of fetal intracranial hemorrhage: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-0576","authenticated-orcid":false,"given":"F. 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