{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:11:29Z","timestamp":1747152689069,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the reproductive outcome after early miscarriage between women managed expectantly and those treated with vaginal misoprostol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a planned secondary analysis of data collected prospectively in a randomized controlled trial comparing expectant management with vaginal misoprostol treatment (single dose of 800\u2009<jats:italic>\u00b5<\/jats:italic>g) in women with early embryonic or anembryonic miscarriage and vaginal bleeding. The outcome measures were the number of women with a clinical pregnancy conceived within 14\u2009months after complete miscarriage and the outcome of these pregnancies in terms of live birth, miscarriage, ectopic pregnancy and legal termination of pregnancy. The participants replied to a questionnaire sent by post covering their reproductive history \u2264\u200914\u2009months after the index miscarriage was complete. Supplementary information and data for women who did not return their questionnaire were retrieved from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 94 women randomized to misoprostol treatment and 95 allocated to expectant management, 94 and 90 women, respectively, were included for analysis. Information on reproductive outcome was available for 89\/94 (95%) and 83\/90 (92%) women, respectively. Complete miscarriage without surgical evacuation was achieved within 31\u2009days in 85% (76\/89) of the women in the misoprostol group and in 65% (54\/83) of those managed expectantly. The proportion of women treated with surgical evacuation was 33% (27\/83) in the expectant\u2010management group <jats:italic>vs<\/jats:italic> 12% (11\/89) in the misoprostol group. At 14\u2009months after the index miscarriage was complete, 75% (67\/89) of women treated with misoprostol and 75% (62\/83) of those managed expectantly had achieved at least one clinical pregnancy, while 40% (36\/89) and 35% (29\/83), respectively, had had at least one live birth (mean difference, 5.5% (95%\u2009CI, \u22129.7 to 20.3%)). When considering the outcome of all pregnancies conceived within 14\u2009months after the index miscarriage was complete, 63% (56\/89) of women in the misoprostol group and 55% (46\/83) of those in the expectant\u2010management group delivered a live baby after a pregnancy (mean difference, 7.5% (95%\u2009CI, \u22127.9 to 22.4%)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with early miscarriage can be reassured that fertility is similar after misoprostol treatment and expectant management. \u00a9 2021 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24769","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T12:21:01Z","timestamp":1631708461000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reproductive outcome after early miscarriage: comparing vaginal misoprostol treatment with expectant management in a planned secondary analysis of a randomized controlled trial"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-9488","authenticated-orcid":false,"given":"A.","family":"Fernlund","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Department of Clinical Sciences Malm\u00f6 Lund University  Malm\u00f6 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