{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:34:19Z","timestamp":1780353259352,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda","doi-asserted-by":"publisher","award":["2020\u20101\u201032"],"award-info":[{"award-number":["2020\u20101\u201032"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) vertical transmission has been investigated extensively. Recently, the World Health Organization (WHO) published strict criteria to classify the timing of mother\u2010to\u2010child transmission of SARS\u2010CoV\u20102 into different categories. The aim of this study was to investigate the possibility of vertical transmission in asymptomatic SARS\u2010CoV\u20102\u2010positive women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women attending for delivery at a perinatology center in Mexico City, Mexico, who had a SARS\u2010CoV\u20102\u2010positive nasopharyngeal swab 24\u201348\u2009h before delivery, were asymptomatic at the time of the test and had an obstetric indication for Cesarean section were eligible for inclusion in this study. Amniotic fluid was collected during Cesarean delivery, and neonatal oral and rectal swabs were collected at birth and at 24\u2009h after birth. SARS\u2010CoV\u20102 detection was carried out using real\u2010time reverse\u2010transcription polymerase chain reaction in all samples. Relevant medical information was retrieved from clinical records. The WHO criteria for classifying the timing of mother\u2010to\u2010child transmission of SARS\u2010CoV\u20102 were applied to the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two SARS\u2010CoV\u20102\u2010positive asymptomatic pregnant women fulfilled the inclusion criteria. Twenty\u2010five (59%) women developed mild disease after discharge. Neonatal death occurred in three (7%) cases, of which one had a positive SARS\u2010CoV\u20102 test at birth and none had coronavirus disease 2019\u2010related symptoms. There were five (12%) cases with strong evidence of intrauterine transmission of SARS\u2010CoV\u20102, according to the WHO criteria, as amniotic fluid samples and neonatal samples at birth and at 24\u2009h after birth were positive for SARS\u2010CoV\u20102. Our results also showed that 40\u201360% of infected neonates would have been undetected if only one swab (oral or rectal) was tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study contributes evidence to reinforce the potential for vertical transmission of SARS\u2010CoV\u20102 even in asymptomatic women and highlights the importance of testing more than one neonatal sample in order to increase the detection rate of SARS\u2010CoV\u20102 in affected cases. \u00a9 2021 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24787","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T02:29:23Z","timestamp":1632796163000},"page":"900-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evidence of possible <scp>SARS\u2010CoV<\/scp>\u20102 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women"],"prefix":"10.1002","volume":"58","author":[{"given":"R.","family":"Sevilla\u2010Montoya","sequence":"first","affiliation":[{"name":"Department of Genetics and Human Genomics National Institute of Perinatology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hidalgo\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Medicine National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Estrada\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Villavicencio\u2010Carrisoza","sequence":"additional","affiliation":[{"name":"Departamento de Inmuno\u2010Bioqu\u00edmica Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"},{"name":"Programa de posgrado en Biomedicina y Biotecnolog\u00eda Molecular Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto Polit\u00e9cnico Nacional  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leon\u2010Juarez","sequence":"additional","affiliation":[{"name":"Departamento de Inmuno\u2010Bioqu\u00edmica Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Villegas\u2010Mota","sequence":"additional","affiliation":[{"name":"Unidad de enfermedades infecciosas y epidemiolog\u00eda, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Espino\u2010y\u2010Sosa","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n Cl\u00ednica Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. E.","family":"Monroy\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Genetics and Human Genomics National Institute of Perinatology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-3857","authenticated-orcid":false,"given":"R. J.","family":"Martinez\u2010Portilla","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n Cl\u00ednica Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-4130","authenticated-orcid":false,"given":"L. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Prince of Wales Hospital, The Chinese University of Hong Kong  Shatin, Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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