{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:08:16Z","timestamp":1792292896572,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the predictive performance of a previously reported competing\u2010risks model of screening for pre\u2010eclampsia (PE) at 35\u201337\u2009weeks' gestation by combinations of maternal risk factors, mean arterial pressure (MAP), uterine artery pulsatility index (UtA\u2010PI), serum placental growth factor (PlGF) and serum soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) in a validation dataset derived from the screened population of the STATIN study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective third\u2010trimester multicenter study of screening for PE in singleton pregnancies by means of a previously reported algorithm that combines maternal risk factors and biomarkers. Women in the high\u2010risk group were invited to participate in a trial of pravastatin <jats:italic>vs<\/jats:italic> placebo, but the trial showed no evidence of an effect of pravastatin in the prevention of PE. Patient\u2010specific risks of delivery with PE were calculated using the competing\u2010risks model, and the performance of screening for PE by maternal risk factors alone and by various combinations of risk factors with MAP, UtA\u2010PI, PlGF and sFlt\u20101 was assessed. The predictive performance of the model was examined by, first, the ability of the model to discriminate between the PE and no\u2010PE groups using the area under the receiver\u2010operating\u2010characteristics curve (AUC) and the detection rate at a fixed false\u2010positive rate of 10%, and, second, calibration by measurements of calibration slope and calibration\u2010in\u2010the\u2010large.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population of 29\u2009677 pregnancies contained 653 that developed PE. In screening for PE by a combination of maternal risk factors, MAP, PlGF and sFlt\u20101 (triple test), the detection rate at a 10% false\u2010positive rate was 79% (95%\u2009CI, 76\u201382%) and the results were consistent with the data used for developing the algorithm. Addition of UtA\u2010PI did not improve the prediction provided by the triple test. The AUC for the triple test was 0.923 (95%\u2009CI, 0.913\u20130.932), demonstrating very high discrimination between affected and unaffected pregnancies. Similarly, the calibration slope was 0.875 (95%\u2009CI, 0.831\u20130.919), demonstrating good agreement between the predicted risk and observed incidence of PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The competing\u2010risks model provides an effective and reproducible method for third\u2010trimester prediction of term PE. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24789","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T02:32:42Z","timestamp":1632796362000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<scp>STATIN<\/scp> trial: predictive performance of competing\u2010risks model in screening for pre\u2010eclampsia at 35\u201337\u2009weeks' gestation"],"prefix":"10.1002","volume":"59","author":[{"given":"M.","family":"D\u00f6bert","sequence":"first","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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L.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca and Institute for Biomedical Research of Murcia, IMIB\u2010Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-5442","authenticated-orcid":false,"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[{"name":"Medway Maritime Hospital, Gillingham  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Muscettola","sequence":"additional","affiliation":[{"name":"Royal London Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Janga","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Singh","sequence":"additional","affiliation":[{"name":"Southend University Hospital, Westcliff\u2010on\u2010Sea  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Martin\u2010Alonso","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Torrej\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"D\u00fctemeyer","sequence":"additional","affiliation":[{"name":"University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"De Alvarado","sequence":"additional","affiliation":[{"name":"Homerton University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Atanasova","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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