{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:41:40Z","timestamp":1775018500947,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013842","name":"Imperial Health Charity","doi-asserted-by":"publisher","award":["RFPrD1920\/116"],"award-info":[{"award-number":["RFPrD1920\/116"]}],"id":[{"id":"10.13039\/100013842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","award":["IS\u2010BRC\u20101215\u201020013"],"award-info":[{"award-number":["IS\u2010BRC\u20101215\u201020013"]}],"id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe and compare the characteristics of ectopic pregnancies (EPs) in the year prior to <jats:italic>vs<\/jats:italic> during the coronavirus disease 2019 (COVID\u201019) pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of women diagnosed with an EP on transvaginal sonography conducted at a center in London, UK, providing early\u2010pregnancy assessment, between 1 January 2019 and 31 December 2020. Women were identified via the Astraia ultrasound reporting system using coded and non\u2010coded outcomes of EP or pregnancy outside the uterine cavity. Data related to predefined outcomes were collected using Astraia and Cerner electronic reporting systems. Main outcome measures included clinical, ultrasound and biochemical features of EP, in addition to reported complications and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 22\u2009683 consultations over the 2\u2010year period. Following consultation, a similar number and proportion of EPs were diagnosed in 2019 (141\/12\u2009657 (1%)) and 2020 (134\/10\u2009026 (1%)). Both cohorts were comparable in age, ethnicity, weight and method of conception. Gestational age at the first transvaginal sonography scan and at diagnosis were similar, and no difference in location, size or morphology of EP was found between the two cohorts. Serum human chorionic gonadotropin (hCG) levels at the time of EP diagnosis were higher in 2020 than in 2019 (1005\u2009IU\/L <jats:italic>vs<\/jats:italic> 665\u2009IU\/L; <jats:italic>P<\/jats:italic>\u2009=\u20090.03). The proportions of women according to type of final EP management were similar, but the rate of failed first\u2010line management was higher during <jats:italic>vs<\/jats:italic> before the pandemic (16% <jats:italic>vs<\/jats:italic> 6%; <jats:italic>P<\/jats:italic>\u2009=\u20090.01). The rates of blood detected in the pelvis (hemoperitoneum) on ultrasound (23% <jats:italic>vs<\/jats:italic> 26%; <jats:italic>P<\/jats:italic>\u2009=\u20090.58) and of ruptured EP confirmed surgically (9% <jats:italic>vs<\/jats:italic> 3%; <jats:italic>P<\/jats:italic>\u2009=\u20090.07) were similar in 2019 <jats:italic>vs<\/jats:italic> 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No difference was observed in the location, size, morphology or gestational age at the first ultrasound examination or at diagnosis of EP between women diagnosed before <jats:italic>vs<\/jats:italic> during the COVID\u201019 pandemic. Complication rates and final management strategy were also unchanged. However, hCG levels and the failure rate of first\u2010line conservative management measures were higher during the pandemic. Our findings suggest that women continued to access appropriate care for EP during the COVID\u201019 pandemic, with no evidence of diagnostic delay or an increase in adverse outcome in our population. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24793","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T04:08:52Z","timestamp":1633406932000},"page":"909-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrasound characteristics, serum biochemistry and outcome of ectopic pregnancies presenting during <scp>COVID<\/scp>\u201019 pandemic"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-5545","authenticated-orcid":false,"given":"C.","family":"Kyriacou","sequence":"first","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"},{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Parker","sequence":"additional","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Barcroft","sequence":"additional","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Letchworth","sequence":"additional","affiliation":[{"name":"St Mary's Hospital, Department of Obstetrics and Gynaecology Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sur","sequence":"additional","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gould","sequence":"additional","affiliation":[{"name":"St Mary's Hospital, Department of Obstetrics and Gynaecology Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Stalder","sequence":"additional","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bourne","sequence":"additional","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research, Department of Obstetrics and Gynaecology, Queen Charlotte's &amp; Chelsea Hospital Imperial College London  London UK"},{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London  London UK"},{"name":"Department of Obstetrics and\u2009Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16431"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1401"},{"key":"e_1_2_8_4_1","unstructured":"BMA.The hidden impact of COVID\u201019 on patient care in the NHS in England 2020.https:\/\/www.bma.org.uk\/media\/2841\/the\u2010hidden\u2010impact\u2010of\u2010covid_web\u2010pdf.pdf."},{"key":"e_1_2_8_5_1","unstructured":"BourneT KyriacouC CoomarasamyA KirkE CondousG LeonardiM Al\u2010MemarM SmallR MorrisE O'BrienP GoodyearG JardineJ RelphS. 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Information for healthcare professionals.Royal College of Obstetricians and Gynaecologists2020.https:\/\/www.rcog.org.uk\/globalassets\/documents\/guidelines\/2020\u201005\u201015\u2010guidance\u2010for\u2010rationalising\u2010early\u2010pregnancy\u2010services\u2010in\u2010the\u2010evolving\u2010coronavirus\u2010covid\u201019\u2010pandemic.pdf."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22046"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22047"},{"key":"e_1_2_8_8_1","article-title":"Expectant care versus surgical treatment for miscarriage","volume":"2012","author":"Nanda K","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22126"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.01.054"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13647"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13925"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1847072"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20211154"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23655"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3310\/hsdr08460"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15442"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20420"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16497"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011864"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy025"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.10.102"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23147"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem283"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2636"},{"key":"e_1_2_8_26_1","unstructured":"The Association of Reproductive and Clinical Scientists (ARCS) and British Fertility Society (BFS) U.K.best practice guidelines for reintroduction of routine fertility treatments during the COVID\u201019 pandemic.2020.https:\/\/www.arcscientists.org\/wp\u2010content\/uploads\/2020\/05\/The\u2010Association\u2010of\u2010Reproductive\u2010and\u2010Clinical\u2010Scientists\u2010ARCS\u2010and\u2010British\u2010Fertility\u2010Society\u2010BFS\u2010U.K.\u2010be22005.pdf."}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.24793","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T08:47:36Z","timestamp":1692866856000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.24793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/uog.24793"],"URL":"https:\/\/doi.org\/10.1002\/uog.24793","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}