{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:39:27Z","timestamp":1768016367662,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In addition to the lungs, the placenta and the endothelium can be affected by severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). Soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) and placental growth factor (PlGF) are markers of endothelial dysfunction and could potentially serve as predictors of severe coronavirus disease 2019 (COVID\u201019). We aimed to investigate the association of serum concentrations of sFlt\u20101 and PlGF with the severity of COVID\u201019 in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective cohort study carried out in a tertiary care hospital in Mexico City, Mexico. Symptomatic pregnant women with a positive reverse\u2010transcription quantitative polymerase chain reaction test for SARS\u2010CoV\u20102 infection who fulfilled the criteria for hospitalization were included. The primary outcome was severe pneumonia due to COVID\u201019. Secondary outcomes were intensive care unit (ICU) admission, viral sepsis and maternal death. sFlt\u20101 levels were expressed as multiples of the median (MoM). The association between sFlt\u20101 and each adverse outcome was explored by logistic regression analysis, adjusted for gestational age for outcomes occurring in more than five patients, and the predictive performance was assessed by receiver\u2010operating\u2010characteristics\u2010curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 113 pregnant women with COVID\u201019, higher sFlt\u20101 MoM was associated with an increased probability of severe pneumonia (adjusted odds ratio (aOR), 1.817 (95%\u2009CI, 1.365\u20132.418)), ICU admission (aOR, 2.195 (95%\u2009CI, 1.582\u20133.047)), viral sepsis (aOR, 2.318 (95%\u2009CI, 1.407\u20133.820)) and maternal death (unadjusted OR, 5.504 (95%\u2009CI, 1.079\u201328.076)). At a 10% false\u2010positive rate, sFlt\u20101 MoM had detection rates of 45.2%, 66.7%, 83.3% and 100% for severe COVID\u201019 pneumonia, ICU admission, viral sepsis and maternal death, respectively. PlGF values were similar between women with severe and those with non\u2010severe COVID\u201019 pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>sFlt\u20101 MoM is higher in pregnant women with severe COVID\u201019 and has the capability to predict serious adverse pregnancy events, such as severe pneumonia, ICU admission, viral sepsis and maternal death. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24798","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T20:54:14Z","timestamp":1634763254000},"page":"202-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased levels of soluble fms\u2010like tyrosine kinase\u20101 are associated with adverse outcome in pregnant women with\u00a0<scp>COVID<\/scp>\u201019"],"prefix":"10.1002","volume":"59","author":[{"given":"J.","family":"Torres\u2010Torres","sequence":"first","affiliation":[{"name":"Maternal\u2013Fetal Medicine Department, General Hospital of Mexico, \u2018Dr Eduardo Liceaga\u2019  Mexico City Mexico"},{"name":"Clinical Research Branch National Institute of Perinatology  Mexico City Mexico"},{"name":"ABC Medical Center, Medical Association  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Espino\u2010y\u2010Sosa","sequence":"additional","affiliation":[{"name":"Clinical Research Branch National Institute of Perinatology  Mexico City Mexico"},{"name":"ABC Medical Center, Medical Association  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-4130","authenticated-orcid":false,"given":"L. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong  Hong Kong SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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