{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:30:37Z","timestamp":1778628637445,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the distribution of birth weight according to gestational age in pregnancies complicated by pre\u2010eclampsia (PE) and assess the potential value of sonographic estimated fetal weight (EFW) at mid\u2010gestation as a predictor of PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data for this study were derived from prospective screening for adverse obstetric outcome in 93\u2009911 women with a singleton pregnancy attending for routine pregnancy care at 19\u2009+\u20090 to 24\u2009+\u20096\u2009weeks' gestation in two UK maternity hospitals. This visit included recording of maternal demographic characteristics and medical history, sonographic EFW and measurement of mean arterial pressure (MAP) and uterine artery pulsatility index (UtA\u2010PI). The distribution of birth weight of pregnancies with and those without PE was assessed. The competing\u2010risks model was used to estimate the individual, patient\u2010specific risk of delivery with PE at &lt;\u200932 and &lt;\u200937\u2009weeks' gestation and at any gestational age. The areas under the receiver\u2010operating\u2010characteristics curves and detection rates (DRs) of delivery with PE, at a 10% false\u2010positive rate (FPR), were assessed for various combinations of maternal risk factors, EFW, MAP and UtA\u2010PI. McNemar's test was used to determine the significance of difference in DR at a 10% FPR between screening with <jats:italic>vs<\/jats:italic> without EFW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population contained 2843 (3.0%) pregnancies that subsequently developed PE, including 148 (0.2%) that delivered with PE at &lt;\u200932\u2009weeks' gestation and 654 (0.7%) that delivered with PE at &lt;\u200937\u2009weeks. Birth weight was &lt;\u200910<jats:sup>th<\/jats:sup> percentile in 82% of pregnancies with PE delivering at &lt;\u200932\u2009weeks' gestation and this decreased to 21% of those with PE delivering at \u2265\u200937\u2009weeks. In screening for delivery with PE at &lt;\u200932 and &lt;\u200937\u2009weeks' gestation, the DR, at a 10% FPR, achieved by maternal risk factors (51% and 46%, respectively) was improved by addition of EFW (69% and 51%, respectively). Similarly, addition of EFW improved the performance of screening by a combination of maternal risk factors and MAP from 72% to 80% for PE\u2009&lt;\u200932\u2009weeks and from 57% to 60% for PE\u2009&lt;\u200937\u2009weeks. EFW did not improve the predictive performance of screening by a combination of maternal risk factors, MAP and UtA\u2010PI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In pregnancies complicated by preterm PE, a high proportion of neonates are small\u2010for\u2010gestational age, and sonographic EFW at mid\u2010gestation can improve the prediction of early and preterm PE provided by maternal risk factors and MAP but not the prediction provided by a combination of maternal risk factors, MAP and UtA\u2010PI. \u00a9 2021 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24829","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T14:49:45Z","timestamp":1638542985000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Estimated fetal weight at mid\u2010gestation in prediction of pre\u2010eclampsia in singleton pregnancy"],"prefix":"10.1002","volume":"59","author":[{"given":"L.","family":"Frei","sequence":"first","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"A.","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Fetal Medicine Research Institute King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-5442","authenticated-orcid":false,"given":"R.","family":"Akolekar","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Medway Maritime Hospital  Gillingham UK"},{"name":"Institute of Medical Sciences Canterbury Christ Church University  Chatham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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