{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:40:45Z","timestamp":1780058445780,"version":"3.54.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2017T075"],"award-info":[{"award-number":["2017T075"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Fetal growth restriction (FGR) may alter brain development permanently, resulting in lifelong structural and functional changes. However, in studies addressing this research question, FGR singletons have been compared primarily to matched appropriately grown singletons, a design which is inherently biased by differences in genetic and maternal factors. To overcome these limitations, we conducted a within\u2010pair comparison of neonatal structural cerebral ultrasound measurements in monochorionic twin pairs with selective FGR (sFGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Structural cerebral measurements on neonatal cerebral ultrasound were compared between the smaller and larger twins of monochorionic twin pairs with sFGR, defined as a birth\u2010weight discordance (BWD) \u2265\u200920%, born in our center between 2010 and 2020. Measurements from each twin pair were also compared with those of an appropriately grown singleton, matched according to sex and gestational age at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Included were 58 twin pairs with sFGR, with a median gestational age at birth of 31.7 (interquartile range, 29.9\u201333.8)\u2009weeks and a median birth weight of 1155\u2009g for the smaller twin and 1725\u2009g for the larger twin (median BWD, 32%). Compared with both the larger twin and the singleton, the smaller twin had significantly smaller cerebral structures (corpus callosum, vermis, cerebellum), less white\/deep gray matter and smaller intracranial surface area and volume. Intracranial\u2010volume discordance and BWD correlated significantly (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.228, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The median intracranial\u2010volume discordance was smaller than the median BWD (19% <jats:italic>vs<\/jats:italic> 32%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). After correction for intracranial volume, only one of the observed differences (biparietal diameter) remained significant for the smaller twin <jats:italic>vs<\/jats:italic> both the larger twin and the singleton.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In monochorionic twins with sFGR, neonatal cerebral ultrasound reveals an overall, proportional restriction in brain growth, with smaller cerebral structures, less white\/deep gray matter and smaller overall brain\u2010size parameters in the smaller twin. There was a positive linear relationship between BWD and intracranial\u2010volume discordance, with intracranial\u2010volume discordance being smaller than BWD. \u00a9 2021 The Authors. <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic> published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24832","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T12:39:56Z","timestamp":1640090396000},"page":"747-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Changes in structural brain development after selective fetal growth restriction in monochorionic twins"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-045X","authenticated-orcid":false,"given":"S. G.","family":"Groene","sequence":"first","affiliation":[{"name":"Neonatology, Willem\u2010Alexander Children's Hospital, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"},{"name":"Molecular Epidemiology, Department of Biomedical Data Sciences Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. S.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Neonatology, Willem\u2010Alexander Children's Hospital, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Slaghekke","sequence":"additional","affiliation":[{"name":"Fetal Therapy, Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-1997","authenticated-orcid":false,"given":"M. C.","family":"Haak","sequence":"additional","affiliation":[{"name":"Fetal Therapy, Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. T.","family":"Heijmans","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology, Department of Biomedical Data Sciences Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Willem\u2010Alexander Children's Hospital, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-5934","authenticated-orcid":false,"given":"A. A. W.","family":"Roest","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Willem\u2010Alexander Children's Hospital, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-5066","authenticated-orcid":false,"given":"E.","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Neonatology, Willem\u2010Alexander Children's Hospital, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-1164","authenticated-orcid":false,"given":"J. M. M.","family":"van Klink","sequence":"additional","affiliation":[{"name":"Neonatology, Willem\u2010Alexander Children's Hospital, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Steggerda","sequence":"additional","affiliation":[{"name":"Neonatology, Willem\u2010Alexander Children's Hospital, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573396314666180712114531"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.12.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357592"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271402"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353631"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-01333-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2019.38"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.05.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20096"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2013.12.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4046"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9041"},{"issue":"383","key":"e_1_2_7_16_1","first-page":"e1","article-title":"From population reference to national standard: new and improved birthweight charts","volume":"220","author":"Hoftiezer L","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_17_1","first-page":"e3208","article-title":"Accurate and simple evaluation of vascular anastomoses in monochorionic placenta using colored dye","volume":"55","author":"Lopriore E","year":"2011","journal-title":"J Vis Exp"},{"key":"e_1_2_7_18_1","unstructured":"Image J.https:\/\/imagej.net\/software\/imagej\/#publication."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2196\/16204"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2013.04.012"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30638-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80189-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.12.900"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.4.569"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2629"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh230"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0553"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.231"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203350109"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.04.031"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4298"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.07.002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.09.006"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31822f129d"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070944"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.24832","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T20:21:56Z","timestamp":1747686116000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.24832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/uog.24832"],"URL":"https:\/\/doi.org\/10.1002\/uog.24832","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}