{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:30:01Z","timestamp":1782739801615,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the predictive performance for delivery with pre\u2010eclampsia (PE) at &lt;\u20093\u2009weeks and at any stage after assessment at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation of serum placental growth factor (PlGF) and soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101)\/PlGF ratio with that of a competing\u2010risks model utilizing maternal risk factors, mean arterial pressure (MAP) and ophthalmic artery peak systolic velocity (PSV) ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study of women attending for a routine hospital visit at 35\u2009+\u20090 to 36\u2009+\u20096\u2009weeks' gestation. This visit included recording of maternal demographic characteristics and medical history, ultrasound examination of fetal anatomy and growth, assessment of flow velocity waveforms from the maternal ophthalmic arteries and measurement of MAP, serum PlGF and serum sFlt\u20101. The performance of screening for delivery with PE at &lt;\u20093\u2009weeks and at any time after the examination was assessed using areas under the receiver\u2010operating\u2010characteristics curves and detection rates (DRs), at a 10% false\u2010positive rate (FPR). McNemar's test was used to compare DRs, at a 10% FPR, between screening by PlGF concentration, the sFlt\u20101\/PlGF concentration ratio and the competing\u2010risks model utilizing maternal risk factors, MAP and ophthalmic artery PSV ratio. Model\u2010based estimates of screening performance for different methods of screening were also produced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population of 2338 pregnancies contained 75 (3.2%) cases that developed PE, including 30 (1.3%) that delivered with PE at &lt;\u20093\u2009weeks from assessment, and 2263 cases unaffected by PE. The DR of PE at &lt;\u20093\u2009weeks from assessment, at a 10% FPR, of sFlt\u20101\/PlGF ratio (70.0% (95%\u2009CI, 50.6\u201385.3%)) was superior to that of PlGF (50.0% (95%\u2009CI, 31.3\u201368.7%)) or PSV ratio (56.7% (95%\u2009CI, 37.4\u201374.5%)) but inferior to that of the combination of maternal risk factors, MAP multiples of the median (MoM) and PSV ratio delta (96.7% (95%\u2009CI, 82.8\u201399.9%)). Similarly, the DR of PE at any stage after assessment of sFlt\u20101\/PlGF ratio (62.7% (95%\u2009CI, 50.7\u201373.6%)) was superior to that of PlGF (52.0% (95%\u2009CI, 40.2\u201363.7%)) or PSV ratio (41.3% (95%\u2009CI, 30.1\u201353.3%)) but inferior to that of the combination of maternal risk factors, MAP MoM and PSV ratio delta (78.7% (95%\u2009CI, 67.7\u201387.3%)). The empirical results for DR at a 10% FPR were consistent with the modeled results, both for delivery with PE at &lt;\u20093\u2009weeks and at any time after assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ophthalmic artery Doppler in combination with maternal risk factors and blood pressure could potentially replace measurement of <jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">sFlt<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">PlGF<\/jats:styled-content> ratio in the prediction of imminent <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>. \u00a9 2022 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24874","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T04:59:15Z","timestamp":1644296355000},"page":"606-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of ophthalmic artery Doppler with <scp>PlGF<\/scp> and <scp>sFlt<\/scp>\u20101\/<scp>PlGF<\/scp> ratio at 35\u201337 weeks' gestation in prediction of imminent pre\u2010eclampsia"],"prefix":"10.1002","volume":"59","author":[{"given":"K.","family":"Lau","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"},{"name":"Antenatal Hypertension Clinic King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sarno","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"},{"name":"Department of Obstetrics and Gynecology Federal University of Bahia (UFBA)  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-6038","authenticated-orcid":false,"given":"N. A.","family":"Kametas","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital  London UK"},{"name":"Antenatal Hypertension Clinic King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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