{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:09:18Z","timestamp":1790694558657,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the long\u2010term outcome of children with prenatally diagnosed isolated complete agenesis of the corpus callosum (cACC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center case series, we reviewed retrospectively the charts of fetuses referred to our fetal therapy unit from January 2004 to July 2020 for a suspected anomaly of the corpus callosum (CC). Cases with prenatally diagnosed isolated cACC were included. Fetal karyotype and comparative genomic hybridization microarray of amniotic fluid, in addition to fetal magnetic resonance imaging, were offered to all pregnant women with a diagnosis of fetal CC malformation. The surviving children were enrolled in the neurodevelopmental follow\u2010up program at our institution, which included postnatal magnetic resonance imaging, serial neurological examinations and neurodevelopmental evaluations with standardized tests according to age. Families living in remote areas or far from our institution were offered a structured <jats:italic>ad\u2010hoc<\/jats:italic> phone interview.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 128 pregnancies with fetal CC malformation were identified (mean gestational age at diagnosis, 24.5 (range, 21\u201334) weeks), of which 53 cases were diagnosed prenatally with apparently isolated cACC. Of these, 12 cases underwent termination of pregnancy, one resulted in intrauterine demise at 24\u2009weeks of gestation and 13 cases were lost to follow\u2010up. Of the remaining 27 children, one was excluded due to an associated chromosomal anomaly (8p21.3q11.21 mosaic duplication) diagnosed after birth, which could have been detected prenatally if the parents had consented to amniocentesis. In the 26 children included in the analysis, neurodevelopmental follow\u2010up was available for a median of 3 (range, 1\u201316) years. Three (11.5%) infants had severe neurodevelopmental impairment, two of which were diagnosed postnatally with a genetic syndrome (Mowat\u2013Wilson syndrome and Vici syndrome) that would not have been diagnosed prenatally. Seven (26.9%) children had mild neurodevelopmental impairment and 16 (61.5%) had normal neurodevelopmental outcome. The Full\u2010Scale Intelligence Quotients of the three children with severe neurodevelopmental impairment were 50, 64 and 63, respectively, while that of the remaining children was in the normal range  (median, 101; range, 89\u2013119).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In 88% of the children with cACC included in this study, neurodevelopment was not severely impaired. However, long\u2010term follow\u2010up is recommended in all cases of congenital isolated cACC to recognize subtle neurodevelopmental disorders as early as possible. \u00a9 2022 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24898","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T13:18:13Z","timestamp":1647004693000},"page":"494-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Long\u2010term outcome of consecutive case series of congenital isolated agenesis of corpus callosum"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-1298","authenticated-orcid":false,"given":"M.","family":"Lanna","sequence":"first","affiliation":[{"name":"Fetal Therapy Unit \u2018U. Nicolini\u2019 Vittore Buzzi Children's Hospital  Milan Italy"},{"name":"Department of Women, Mother and Neonate Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Scelsa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cutillo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Amendolara","sequence":"additional","affiliation":[{"name":"Department of Women, Mother and Neonate Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Doneda","sequence":"additional","affiliation":[{"name":"Department of Radiology and Neuroradiology Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Balestriero","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5537-7145","authenticated-orcid":false,"given":"S.","family":"Faiola","sequence":"additional","affiliation":[{"name":"Fetal Therapy Unit \u2018U. Nicolini\u2019 Vittore Buzzi Children's Hospital  Milan Italy"},{"name":"Department of Women, Mother and Neonate Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Casati","sequence":"additional","affiliation":[{"name":"Fetal Therapy Unit \u2018U. Nicolini\u2019 Vittore Buzzi Children's Hospital  Milan Italy"},{"name":"Department of Women, Mother and Neonate Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Spaccini","sequence":"additional","affiliation":[{"name":"Clinical Genetic Service Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Women, Mother and Neonate Vittore Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2320-07.2007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23472"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.072"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22145"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23616"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13958"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512534"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5878-0"},{"key":"e_1_2_7_10_1","volume-title":"The abilities of young children","author":"Griffiths R.","year":"1984"},{"key":"e_1_2_7_11_1","volume-title":"Wechsler Preschool and Primary Scale of Intelligence","author":"Wechsler D.","year":"2002"},{"key":"e_1_2_7_12_1","volume-title":"Wechsler Intelligence Scale for Children","author":"Wechsler D.","year":"2003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3824"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0781-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13217"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04224-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2018.08.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5158"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.24898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.24898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:29:49Z","timestamp":1692674989000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.24898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/uog.24898"],"URL":"https:\/\/doi.org\/10.1002\/uog.24898","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2021-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}