{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:56Z","timestamp":1786978556994,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pre\u2010eclampsia is a vascular complication of pregnancy, associated with a long\u2010term risk of cerebrovascular and mental disorders. We explored whether formerly pre\u2010eclamptic women exhibit differences in functional brain organization, especially in regions that may explain the commonly reported emotional symptoms and cognitive complaints even years after the pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Formerly pre\u2010eclamptic women and control women with a history of normotensive pregnancy underwent structural and functional 7\u2010Tesla magnetic resonance imaging scans. Using graph theoretical analysis, the efficiency and clustering coefficient of the functional brain network were investigated. The study included local analysis focusing on particular brain structures, such as the limbic system and the prefrontal cortex, and global analysis of the whole cerebrum. Univariable and multivariable linear regression was used to investigate the relationship between brain network\u2010related graph measures and the group (formerly pre\u2010eclamptic or control).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 17 control parous women and 55 women with a history of pre\u2010eclampsia were recruited. The time intervals between the index pregnancy and recruitment were 8.0 and 5.6\u2009years for the two groups, respectively. Compared with control women, formerly pre\u2010eclamptic women had higher local efficiency in the prefrontal cortex (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.048) and anterior cingulate cortex (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03) but lower local efficiency and local clustering coefficient in the amygdala (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.004 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02, respectively) and parahippocampal cortex (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008, respectively). No differences were found in the global functional brain organization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Compared to controls with a history of normotensive pregnancy, formerly pre\u2010eclamptic women displayed a different local functional brain organization. These differences in functional connectivity, especially in the limbic regions and the prefrontal cortex, are in line with the psychological and cognitive complaints reported commonly by women with a history of pre\u2010eclampsia. \u00a9 2022 The Authors.\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.24928","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T01:24:16Z","timestamp":1651541056000},"page":"532-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional connectivity of limbic system and prefrontal cortex years after pre\u2010eclampsia:\n                    <scp>7\u2010Tesla<\/scp>\n                    functional magnetic resonance imaging study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-2670","authenticated-orcid":false,"given":"L. P. W.","family":"Canjels","sequence":"first","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"MHeNs, School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ghossein\u2010Doha","sequence":"additional","affiliation":[{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"GROW, School for Oncology and Developmental Biology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"CARIM, School for Cardiovascular Diseases Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Alers","sequence":"additional","affiliation":[{"name":"GROW, School for Oncology and Developmental Biology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Gynaecology and Obstetrics Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rutten","sequence":"additional","affiliation":[{"name":"Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht The Netherlands"},{"name":"Scannexus Ultra\u2010High Field MRI Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van den Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"MHeNs, School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-0821","authenticated-orcid":false,"given":"V. M. M. M.","family":"Schiffer","sequence":"additional","affiliation":[{"name":"GROW, School for Oncology and Developmental Biology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Gynaecology and Obstetrics Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-8528","authenticated-orcid":false,"given":"E.","family":"Mulder","sequence":"additional","affiliation":[{"name":"GROW, School for Oncology and Developmental Biology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Gynaecology and Obstetrics Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Gerretsen","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Aldenkamp","sequence":"additional","affiliation":[{"name":"MHeNs, School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"},{"name":"Department of Electrical Engineering Eindhoven University of Technology  Eindhoven The Netherlands"},{"name":"Academic Center for Epileptology Kempenhaeghe\/Maastricht UMC+  Heeze and Maastricht The Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. P. M.","family":"Hurks","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"van de Ven","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E. A.","family":"Spaanderman","sequence":"additional","affiliation":[{"name":"GROW, School for Oncology and Developmental Biology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Gynaecology and Obstetrics Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F. 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