{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:13:56Z","timestamp":1790766836949,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the performance and impact of first\u2010trimester preterm pre\u2010eclampsia screening in a single center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010center study of women with a singleton pregnancy who were screened prospectively for preterm pre\u2010eclampsia (i.e. delivery before 37\u2009weeks' gestation) using maternal characteristics, mean arterial pressure (MAP), uterine artery Doppler pulsatility index, maternal serum pregnancy\u2010associated plasma protein\u2010A and placental growth factor. The individual risk for preterm pre\u2010eclampsia was estimated from a published model, and those with a risk above 1 in 200 were recommended to take 150\u2009mg soluble aspirin per day until 34\u2009weeks. Information on the incidence of pre\u2010eclampsia was obtained from the hospital register of adverse pregnancy outcomes. Screening performance indicators, including detection and false\u2010positive rates, were estimated from the distribution of risks. Screening impact was estimated by dividing the observed prevalence by the expected prevalence, which was derived from the distribution of risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The distributions of MAP, uterine artery Doppler pulsatility index and serum markers were consistent with the risk model parameters. The estimated detection and false\u2010positive rates were 79.7% and 16.2%, respectively. There were six cases of preterm pre\u2010eclampsia, four of which occurred in women with a positive screening result. The prevalence was 62% of that expected, but the 95%\u2009CI of 23\u2013140% indicated that the study was underpowered to assess the impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that the performance of preterm pre\u2010eclampsia screening can be estimated in a single center with fewer than 2000 women screened. However, in order to assess the impact of screening on the prevalence of the condition, a much larger cohort is needed. \u00a9 2022 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.24956","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T12:29:31Z","timestamp":1653740971000},"page":"746-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quality assessment of first\u2010trimester screening for preterm pre\u2010eclampsia"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-7680","authenticated-orcid":false,"given":"I.","family":"Dhaifalah","sequence":"first","affiliation":[{"name":"Fetal Medicine and Genetics Center (FETMED)  Olomouc Czech Republic"},{"name":"Department of Obstetrics and Gynaecology Tomas Bata Regional Hospital  Zlin, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Magalova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Tomas Bata Regional Hospital  Zlin, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Studnykova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Tomas Bata Regional Hospital  Zlin, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Havalova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Tomas Bata Regional Hospital  Zlin, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Slintakova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Tomas Bata Regional Hospital  Zlin, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-2403","authenticated-orcid":false,"given":"H.","family":"Cuckle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18816"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.034"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17399"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19112"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22093"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.09.041"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.02.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40556-019-00236-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.09.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"w14498","DOI":"10.4414\/smw.2017.14498","article-title":"First trimester combined screening for preeclampsia and small for gestational age\u00a0\u2013\u00a0a single centre experience and validation of the FMF screening algorithm","volume":"147","author":"Mosimann B","year":"2017","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14819"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1712124"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20182"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335366"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5157"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.02.018"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23523"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.08.110"}],"container-title":["Ultrasound in Obstetrics &amp; 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