{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:21:49Z","timestamp":1782915709302,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the associated cardiac and extracardiac findings and estimate the prevalence of single left superior vena cava (LSVC) among fetuses referred for fetal echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective case series of fetuses diagnosed with situs solitus and single LSVC at the Brompton Centre for Fetal Cardiology, London, UK, from October 2006 to December 2020. Prenatal and postnatal outcome data were collected. Prenatal diagnosis was based on abnormal vessel alignment at the three\u2010vessel view and\/or three\u2010vessel\u2010and\u2010trachea view, showing a vessel to the left of the pulmonary artery (i.e. the LSVC) and absence of the usual vessel to the right of the ascending aorta (i.e. the right superior vena cava), and further visualization of the LSVC draining into the coronary sinus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 19\u2009968 fetal echocardiograms performed during the study period, 34 cases of single LSVC were identified (a prevalence of 0.17%). Of these, 32 pregnancies had a live birth, one was lost to follow\u2010up and one resulted in intrauterine demise. Single LSVC was isolated in 79.4% of cases. No major congenital heart disease was identified. One fetus showed mild isthmus hypoplasia, with no aortic coarctation postnatally. Two fetuses had umbilical vessel abnormalities. A genetic abnormality was found in one case (15q24.1\u2010q24.2 deletion).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antenatal diagnosis of single LSVC in the setting of situs solitus is usually a benign isolated finding. Nevertheless, investigation of other cardiac, extracardiac and genetic disorders should be considered. \u00a9 2022 The Authors. Ultrasound in Obstetrics &amp; Gynecology published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24966","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:23:17Z","timestamp":1654248197000},"page":"640-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Single left superior vena cava: antenatal diagnosis, associated anomalies and outcomes"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-145X","authenticated-orcid":false,"given":"K. R. M.","family":"Lopes","sequence":"first","affiliation":[{"name":"Brompton Centre for Fetal Cardiology Royal Brompton and Harefield Hospitals  London UK"},{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4599-2002","authenticated-orcid":false,"given":"M.","family":"Bartsota","sequence":"additional","affiliation":[{"name":"Brompton Centre for Fetal Cardiology Royal Brompton and Harefield Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-686X","authenticated-orcid":false,"given":"V.","family":"Doughty","sequence":"additional","affiliation":[{"name":"Brompton Centre for Fetal Cardiology Royal Brompton and Harefield Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-5828","authenticated-orcid":false,"given":"J. S.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Brompton Centre for Fetal Cardiology Royal Brompton and Harefield Hospitals  London UK"},{"name":"Fetal Medicine Unit St George's University Hospitals NHS Foundation Trust  London UK"},{"name":"Cardiovascular Clinical Academic Group St George's University of London Molecular and Clinical Sciences Research Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4801"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4045"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4380"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90228-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00314-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.57.5.474"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-1264-1"},{"issue":"40","key":"e_1_2_8_9_1","first-page":"261","article-title":"Prenatal diagnosis of persistent left and absent right superior vena cava","volume":"2013","author":"Higuchi T","year":"2001","journal-title":"J Med Ultrason"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115000268"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1483"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2699"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.15557\/JoU.2020.0023"},{"key":"e_1_2_8_14_1","unstructured":"Public Health England.Fetal anomaly screening programme: standards(2015):https:\/\/www.gov.uk\/government\/publications\/fetal\u2010anomaly\u2010screening\u2010programme\u2010standards. 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