{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:08:40Z","timestamp":1784894920743,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate and compare the diagnostic test accuracy (DTA) of three\u2010dimensional transvaginal ultrasound (3D\u2010TVS) and magnetic resonance imaging (MRI) for deep myometrial infiltration (DMI) and cervical invasion for preoperative staging and surgery planning in patients with endometrial cancer (EC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review and meta\u2010analysis investigated the DTA of MRI and 3D\u2010TVS for DMI and cervical invasion in patients with EC. A literature search was performed using MEDLINE, Scopus, EMBASE, ScienceDirect, The Cochrane library, \n<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, Cochrane Central Register of Controlled Trials, EU Clinical Trials Register and World Health Organization International Clinical Trials Registry Platform to identify relevant studies published between January 2000 and December 2021. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies\u20102 (QUADAS\u20102) tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five studies, including a total of 450 patients, were included in the systematic review. All five studies compared the DTA of 3D\u2010TVS <jats:italic>vs<\/jats:italic> MRI for DMI, and three studies compared the DTA of 3D\u2010TVS <jats:italic>vs<\/jats:italic> MRI for cervical invasion. Pooled sensitivity, positive likelihood ratio and negative likelihood ratio for detecting DMI using 3D\u2010TVS were 77% (95%\u2009CI, 66\u201385%), 4.57 and 0.31, respectively. The respective values for detecting DMI on MRI were 80% (95%\u2009CI, 73\u201386%), 4.22 and 0.24. Bivariate metaregression indicated a similar DTA of 3D\u2010TVS and MRI (<jats:italic>P<\/jats:italic>\u2009=\u20090.80) for the correct identification of DMI. Pooled ln diagnostic odds ratio for detecting cervical invasion was 3.11 (95%\u2009CI, 2.09\u20134.14) for 3D\u2010TVS and 2.36 (95%\u2009CI, 0.90\u20133.83) for MRI. The risk of bias was low for most of the four domains assessed in QUADAS\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>3D\u2010TVS demonstrated good diagnostic accuracy in terms of sensitivity and specificity for the evaluation of DMI and cervical invasion, with results comparable with those of MRI. Thus, we confirmed the potential role of 3D\u2010TVS in the preoperative staging and surgery planning in patients with EC. \u00a9 2022 The Authors. Ultrasound in Obstetrics &amp; Gynecology published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.24967","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:16:06Z","timestamp":1654247766000},"page":"604-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Three\u2010dimensional transvaginal ultrasound <i>vs<\/i> magnetic resonance imaging for preoperative staging of deep myometrial and cervical invasion in patients with endometrial cancer: systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-0571","authenticated-orcid":false,"given":"G.","family":"Spagnol","sequence":"first","affiliation":[{"name":"Department of Women and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-6001","authenticated-orcid":false,"given":"M.","family":"Noventa","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bonaldo","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vitagliano","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2802","authenticated-orcid":false,"given":"A. 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