{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:49:37Z","timestamp":1791992977012,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Congenital cytomegalovirus (CMV) infection is the leading cause of non\u2010genetic hearing and neurological deficits. The aim of our study was to evaluate the efficacy and safety of valacyclovir (VCV) treatment in preventing CMV transmission to the fetus after maternal primary infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, multicenter study evaluating the rate of maternal\u2013fetal CMV transmission in pregnancies with maternal primary CMV infection treated with VCV at a dosage of 8\u2009g per day (VCV group) compared with a control group of untreated women. Each case underwent virological testing to confirm maternal primary infection and to provide accurate dating of onset of infection. The primary outcome was the presence of congenital CMV infection at birth diagnosed based on polymerase chain reaction analysis of saliva, urine and\/or blood samples. The efficacy of VCV treatment was assessed using logistic regression analysis adjusted for a propensity score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 143 patients were included in the final analysis, of whom 59 were in the VCV group and 84 were in the untreated control group. On propensity\u2010score\u2010adjusted analysis, VCV treatment was significantly associated with an overall reduction in the rate of maternal\u2013fetal CMV transmission (odds ratio, 0.40 (95%\u2009CI, 0.18\u20130.90); <jats:italic>P<\/jats:italic>\u2009=\u20090.029). The rate of maternal\u2013fetal CMV transmission, determined at birth, in the VCV <jats:italic>vs<\/jats:italic> control group was 7% (1\/14) <jats:italic>vs<\/jats:italic> 10% (1\/10) after periconceptional maternal primary infection (<jats:italic>P<\/jats:italic>\u2009=\u20091.00), 22% (8\/36) <jats:italic>vs<\/jats:italic> 41% (19\/46) after first\u2010trimester maternal primary infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.068) and 25% (2\/8) <jats:italic>vs<\/jats:italic> 52% (14\/27) after second\u2010trimester maternal primary infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.244). When analyzing the efficacy of VCV treatment according to maternal viremia at treatment initiation, there was a trend towards greater efficacy when patients were viremia\u2010positive (21% <jats:italic>vs<\/jats:italic> 43%; <jats:italic>P<\/jats:italic>\u2009=\u20090.072) compared with when they were viremia\u2010negative (22% <jats:italic>vs<\/jats:italic> 17%; <jats:italic>P<\/jats:italic>\u2009=\u20090.659). Maternal side effects associated with VCV were mild and non\u2010specific in most cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that VCV treatment of pregnant women with primary CMV infection reduces the risk of maternal\u2013fetal transmission of CMV and may be effective in cases with primary infection in the first and second trimesters. \u00a9 2022 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.26039","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T19:13:14Z","timestamp":1659035594000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["New data on efficacy of valacyclovir in secondary prevention of maternal\u2013fetal transmission of cytomegalovirus"],"prefix":"10.1002","volume":"61","author":[{"given":"C.","family":"Egloff","sequence":"first","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital Louis\u2010Mourier, AP\u2010HP  Colombes France"},{"name":"University of Paris  Paris France"},{"name":"IAME, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sibiude","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital Louis\u2010Mourier, AP\u2010HP  Colombes France"},{"name":"University of Paris  Paris France"},{"name":"IAME, INSERM  Paris France"},{"name":"FHU PREMA  Paris France"},{"name":"Research Group on Infections during Pregnancy (GRIG)  Velizy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vauloup\u2010Fellous","sequence":"additional","affiliation":[{"name":"Research Group on Infections during Pregnancy (GRIG)  Velizy France"},{"name":"Virology Department H\u00f4pital Paul\u2010Brousse, INSERM U1993, Universit\u00e9 Paris Saclay, AP\u2010HP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Benachi","sequence":"additional","affiliation":[{"name":"Research Group on Infections during Pregnancy (GRIG)  Velizy France"},{"name":"Department of Obstetrics and Gynecology, DMU Sant\u00e9 des Femmes et des Nouveau\u2010n\u00e9s H\u00f4pital Antoine B\u00e9cl\u00e8re, Paris Saclay University, AP\u2010HP  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bouthry","sequence":"additional","affiliation":[{"name":"Research Group on Infections during Pregnancy (GRIG)  Velizy France"},{"name":"Department of Biology of Infectious Agents Angers University Hospital  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Biquard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Angers University Hospital  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-4846","authenticated-orcid":false,"given":"A.","family":"Hawkins\u2010Villarreal","sequence":"additional","affiliation":[{"name":"BCNatal Fetal Medicine Research Center, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u Universitat de Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Fetal Medicine Service, Obstetrics Department, Santo Tom\u00e1s Hospital University of Panama  Panama City Panama (on behalf of the Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Houhou\u2010Fidouh","sequence":"additional","affiliation":[{"name":"Virology Department H\u00f4pital Bichat Claude\u2010Bernard, Universit\u00e9 de Paris, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique, H\u00f4pital Louis\u2010Mourier, AP\u2010HP  Colombes France"},{"name":"University of Paris  Paris France"},{"name":"IAME, INSERM  Paris France"},{"name":"FHU PREMA  Paris France"},{"name":"Research Group on Infections during Pregnancy (GRIG)  Velizy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-0047","authenticated-orcid":false,"given":"A. 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